1 Paracrine interactions in the anterior pituitary

Clinics in Endocrinology and Metabolism Pub Date : 1986-02-01 DOI:10.1016/S0300-595X(86)80040-8

Carl Denef

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引用次数: 68

Abstract

The topographical affinity between certain cell types in rat anterior pituitary as well as the presence of biogenic amines, neuropeptides, growth and tissue factors in specific cell types suggest participation of paracrine control mechanisms in the regulation of anterior pituitary hormone secretion. Due to the recent advances in the separation of pituitary cell types and the development of three-dimensional cell cultures, direct experimental evidence for control by intercellular messengers has become available. The stimulation of PRL release from superfused pituitary cell aggregates by LHRH has been shown to be mediated by gonadotrophs. Gonadotrophs appear to secrete a factor with PRL-releasing activity. Gonadotrophs also modulate the stimulation of PRL release by angiotensin II. Interaction of somatotrophs with an unknown small-sized cell type strongly amplifies the GH response to adrenaline, GRF and VIP. The latter phenomenon requires the permissive action of glucocorticoids. Some of these in vitro observations can be correlated with recently reported in vivo actions of LHRH, PRL and angiotensin II and with pathophysiological changes in the pituitary.

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垂体前叶旁分泌的相互作用

大鼠垂体前叶某些细胞类型之间的地形亲和性以及特定细胞类型中生物胺、神经肽、生长因子和组织因子的存在提示旁分泌控制机制参与了垂体前叶激素分泌的调节。由于近年来垂体细胞类型的分离和三维细胞培养的发展，细胞间信使控制的直接实验证据已经成为可能。LHRH刺激垂体过剩细胞聚集体释放PRL已被证明是由促性腺激素介导的。促性腺激素似乎分泌一种具有prl释放活性的因子。促性腺激素也可以调节血管紧张素II对PRL释放的刺激。生长因子与一种未知的小细胞类型的相互作用强烈地放大了生长激素对肾上腺素、GRF和VIP的反应。后一种现象需要糖皮质激素的容许作用。其中一些体外观察结果可以与最近报道的LHRH、PRL和血管紧张素II的体内作用以及垂体的病理生理变化相关联。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Clinics in Endocrinology and Metabolism

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