Synthesis, characterization and antioxidative capacity of nickel(II) and zinc(II) complexes with 4-methylpyrazole

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2024-09-05 DOI:10.1016/j.ica.2024.122363

David Kočović , Berta Barta Holló , Ivana Borišev , Vukadin Leovac , Ljiljana Vojinović Ješić , Gerald Giester , Sergiu Shova , Zoran D. Tomić , Željko Jaćimović

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Abstract

In this paper, the coordination of 4-methylpyrazole (L) to Ni(II) and Zn(II) ions is studied through the reactions of Ni(OAc)₂·4H₂O and Zn(OAc)₂·2H₂O with 4-methylpyrazole in a 1:2 metal-to-ligand molar ratio in ethanol at room temperature. From the reaction mixtures, new complex compounds of formulae: [Ni(OAc)₂L₄] and [Zn(OAc)₂L₂] were crystallized. The crystal and molecular structure of the synthesized complexes were determined by single-crystal X-ray structure analysis. The coordination environment of Ni(II) in its complex is octahedral, while that of Zn(II) is tetrahedral. The compounds are characterized by IR spectra and elemental analysis. Their thermal stability, a crucial property, is analyzed by thermogravimetry. To get a better insight into the decomposition mechanism coupled TG-MS measurements were carried out, too. The tests of the antioxidative activity of the new complexes on DPPH radical showed that the Zn(II) complex is more effective than the Ni(II) complex.

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镍（II）和锌（II）与 4-甲基吡唑配合物的合成、表征和抗氧化能力

本文通过 Ni(OAc)2-4H2O 和 Zn(OAc)2-2H₂O 与 4-甲基吡唑在室温乙醇中以 1:2 的金属与配体摩尔比发生的反应，研究了 4-甲基吡唑 (L) 与 Ni(II) 和 Zn(II) 离子的配位。反应混合物中产生了新的复合物，其化学式为[Ni(OAc)2L4]和[Zn(OAc)2L2]。通过单晶 X 射线结构分析，确定了合成复合物的晶体和分子结构。配合物中 Ni(II) 的配位环境为八面体，而 Zn(II) 的配位环境为四面体。这些化合物通过红外光谱和元素分析进行了表征。它们的热稳定性这一重要特性通过热重法进行了分析。为了更好地了解分解机制，还进行了 TG-MS 联用测量。新复合物对 DPPH 自由基的抗氧化活性测试表明，Zn（II）复合物比 Ni（II）复合物更有效。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.