Venous intracerebral hemorrhage hypotheses: Hydrostatic pressure-induced bleeding mechanism and comparative analysis with arterial hemorrhage

IF 2.1 4区医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL

Medical hypotheses Pub Date : 2024-09-02 DOI:10.1016/j.mehy.2024.111477

Ziqi Li , Huanxiang Huang , Jun Li , Shuwen Mu , Yi Fang , Xinhua Tian , Shousen Wang

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引用次数: 0

Abstract

This study establishes a hypothesis on cerebral venous thrombosis (CVT)-induced intracerebral hemorrhage (ICH), emphasizing distinctive computer tomography (CT) imaging features indicative of venous origin hemorrhages—characterized by lower CT values, diffuse cloud-like appearances, and indistinct borders, attributed to the dynamics of venous bleeding and plasma-dominated blood composition. It further delineates the unique propagation pattern of venous ICH, favoring slow diffusion through white matter tracts rather than entering sulci or breaching the arachnoid membrane, and highlights the susceptibility of specific brain regions due to their venous architecture. Contrasting these findings with arterial ICH, the paper argues for the need for tailored diagnostic and therapeutic approaches. It concludes with a discussion on future research directions, focusing on the development of novel diagnostic tools and treatment modalities specific to venous ICH.

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静脉脑内出血假说：静水压诱发出血机制及与动脉出血的比较分析

本研究提出了脑静脉血栓（CVT）诱发脑内出血（ICH）的假说，强调了静脉源性出血的独特计算机断层扫描（CT）成像特征，即较低的 CT 值、弥漫性云雾状外观和模糊的边界，这归因于静脉出血的动态性和以血浆为主的血液成分。它进一步描述了静脉性 ICH 的独特传播模式，即偏向于通过白质束缓慢扩散，而不是进入脑沟或突破蛛网膜，并强调了特定脑区因其静脉结构而易受影响。本文将这些研究结果与动脉性 ICH 进行对比，认为有必要采用量身定制的诊断和治疗方法。文章最后讨论了未来的研究方向，重点是针对静脉 ICH 开发新型诊断工具和治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical hypotheses 医学-医学：研究与实验

CiteScore

10.60

自引率

2.10%

发文量

167

审稿时长

60 days

期刊介绍： Medical Hypotheses is a forum for ideas in medicine and related biomedical sciences. It will publish interesting and important theoretical papers that foster the diversity and debate upon which the scientific process thrives. The Aims and Scope of Medical Hypotheses are no different now from what was proposed by the founder of the journal, the late Dr David Horrobin. In his introduction to the first issue of the Journal, he asks ''what sorts of papers will be published in Medical Hypotheses? and goes on to answer ''Medical Hypotheses will publish papers which describe theories, ideas which have a great deal of observational support and some hypotheses where experimental support is yet fragmentary''. (Horrobin DF, 1975 Ideas in Biomedical Science: Reasons for the foundation of Medical Hypotheses. Medical Hypotheses Volume 1, Issue 1, January-February 1975, Pages 1-2.). Medical Hypotheses was therefore launched, and still exists today, to give novel, radical new ideas and speculations in medicine open-minded consideration, opening the field to radical hypotheses which would be rejected by most conventional journals. Papers in Medical Hypotheses take a standard scientific form in terms of style, structure and referencing. The journal therefore constitutes a bridge between cutting-edge theory and the mainstream of medical and scientific communication, which ideas must eventually enter if they are to be critiqued and tested against observations.