The emerging role of Rituximab in the treatment of large granular lymphocytic leukemia associated with rheumatoid arthritis: a single center experience.

IF 1.4 4区 医学 Q3 RHEUMATOLOGY
ARP Rheumatology Pub Date : 2024-06-22
Mariana Diz Lopes, Carlos Marques Gomes, Inês Santos, Teresa Martins-Rocha, Miguel Bernardes, José Pinto, Lúcia Costa
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引用次数: 0

Abstract

Large Granular Lymphocytic (LGL) leukemia is a rare lymphoproliferative disorder with a peculiar association with Rheumatoid Arthritis (RA). The most common feature is neutropenia and patients can have splenomegaly, resembling Felty's Syndrome. These diseases have similar clinical and laboratory abnormalities, but the diagnosis of T-cell LGL (T-LGL) leukemia requires evidence of clonality. Even though T-LGL leukemia is indolent in most cases, inadequate treatment when it is indicated can lead to significant morbidity and mortality, mainly associated with recurrent infections. We present two clinical cases that emphasize the emerging role of Rituximab as an effective therapeutic option in patients with T-LGL and RA.

利妥昔单抗在治疗伴有类风湿性关节炎的大颗粒淋巴细胞白血病中的新作用:单中心经验。
大颗粒淋巴细胞(LGL)白血病是一种罕见的淋巴增生性疾病,与类风湿性关节炎(RA)有特殊的关联。最常见的特征是中性粒细胞减少,患者可有脾肿大,类似费尔蒂综合征。这些疾病具有相似的临床和实验室异常,但 T 细胞 LGL(T-LGL)白血病的诊断需要克隆证据。尽管T-LGL白血病在大多数情况下并不严重,但如果治疗不当,可能会导致严重的发病率和死亡率,主要与反复感染有关。我们介绍了两个临床病例,强调了利妥昔单抗作为一种有效的治疗方案在T-LGL和RA患者中的新作用。
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