Sex-related differences concerning the profile and evolution of cardiovascular complications in patients with post-acute COVID-19 syndrome

IF 5.2 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2024-09-04 DOI:10.1016/j.lfs.2024.123044

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引用次数: 0

Abstract

Background

During the COVID-19 pandemic sex-related differences concerning the spectrum of cardiovascular complications have been observed in the acute infection, and during recovery. This study aims to emphasize sex-related disparities regarding left ventricular systolic function (LVSF), right ventricular function (RVF), diastolic dysfunction (DD), and pericardial pathologies during the post-COVID-19 syndrome.

Methods

274 patients with post-acute COVID-19 syndrome, 127 men and 147 women, aged under 55, were evaluated within 90 days after the acute illness and followed at 3 and 6 months.

Results

Based on detailed transthoracic echocardiography (TTE), we identified significantly more frequently (p˂0.001) altered LVSF in men, while in women impaired RVF, and DD were significantly more common (p˂0.001). Pericardial impairment did not seem to be influenced by gender. The TTE parameters characterizing these patterns were correlated with the severity of the initial infection and the time elapsed since and alleviated in time. The multivariate regression analysis confirmed these sex-related associations and their impact on patients' functional status.

Conclusions

Male patients had a higher tendency to develop altered LVSF, while female subjects had more frequently impaired RVF and DD. These abnormalities alleviated in time and exerted a significant influence on patients' functional status.

查看原文本刊更多论文

急性 COVID-19 后综合征患者心血管并发症的概况和演变过程中的性别差异。

背景：在 COVID-19 大流行期间，人们观察到在急性感染和恢复期心血管并发症方面存在性别差异。本研究旨在强调 COVID-19 后综合征期间与左心室收缩功能（LVSF）、右心室功能（RVF）、舒张功能障碍（DD）和心包病变有关的性别差异。方法：在急性病后 90 天内评估了 274 名 COVID-19 后综合征患者，其中男性 127 人，女性 147 人，年龄均在 55 岁以下，并进行了 3 个月和 6 个月的随访：根据详细的经胸超声心动图（TTE），我们发现男性左心室舒张功能（LVSF）改变的频率明显更高（p˂0.001），而女性左心室舒张功能（RVF）受损和右心室舒张功能（DD）改变的频率明显更高（p˂0.001）。心包受损似乎不受性别影响。表征这些模式的 TTE 参数与初始感染的严重程度和感染后的时间相关，并随着时间的推移而减轻。多变量回归分析证实了这些与性别相关的关联及其对患者功能状态的影响：结论：男性患者更易出现左心室收缩力改变，而女性患者则更常出现左心室收缩力和右心室收缩力受损。这些异常会逐渐缓解，并对患者的功能状态产生重要影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.