Trends on Prevalence, All-Cause Mortality, and Survival Status of Dementia Patients in Rural China Based on Pooling Analysis.

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Applied Bio Materials Pub Date : 2024-08-22 eCollection Date: 2024-01-01 DOI:10.3389/ijph.2024.1606786

Kang Huo, Suhang Shang, Jin Wang, Chen Chen, Liangjun Dang, Ling Gao, Shan Wei, Lingxia Zeng, Qiumin Qu

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引用次数: 0

Abstract

Objectives: No study has reported secular trends in dementia prevalence, all-cause mortality, and survival status in rural China.

Methods: We established two cohorts (XRRCC1 and XRRCC2) in the same region of China, 17 years apart, to compare dementia prevalence, all-cause mortality, and survival status, and performed regression analysis to identify associated factors.

Results: Dementia prevalence was 3.49% in XRRCC1 and 4.25% in XRRCC2, with XRRCC2 showing a significantly higher prevalence (OR = 1.79, 95%CI: 1.2-2.65). All-cause mortality rates for dementia patients were 62.0% in XRRCC1 and 35.7% in XRRCC2. Mortality in the normal population of XRRCC2 decreased by 66% compared to XRRCC1, mainly due to improved survival rates in women with dementia. Dementia prevalence was positively associated with age >65, spouse-absent status, and stroke, and negatively associated with ≥6 years of education.

Conclusion: Dementia prevalence in rural China increased over 17 years, while mortality decreased. Major risk factors include aging, no spouse, and stroke, with higher education offering some protection.

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基于汇集分析的中国农村痴呆症患者患病率、全因死亡率和生存状况的趋势。

研究目的方法：我们在中国同一地区建立了两个队列（XRRCC1 和 XRRCC2），相隔 17 年：我们在中国同一地区建立了两个队列（XRRCC1 和 XRRCC2），相隔 17 年，比较痴呆患病率、全因死亡率和生存状况，并进行回归分析以确定相关因素：XRRCC1和XRRCC2的痴呆患病率分别为3.49%和4.25%，其中XRRCC2的痴呆患病率明显更高（OR=1.79，95%CI：1.2-2.65）。痴呆症患者的全因死亡率在 XRRCC1 中为 62.0%，在 XRRCC2 中为 35.7%。与 XRRCC1 相比，XRRCC2 正常人群的死亡率降低了 66%，这主要是因为痴呆症女性患者的存活率提高了。痴呆症患病率与年龄大于 65 岁、无配偶和中风呈正相关，与受教育时间≥6 年呈负相关：结论：中国农村痴呆症患病率在 17 年间有所上升，而死亡率有所下降。主要风险因素包括高龄、无配偶和中风，而高学历则提供了一定的保护。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Applied Bio Materials Chemistry-Chemistry (all)

CiteScore

9.40

自引率

2.10%

发文量

464