Double gammopathies: incidence and clinical course of 20 patients.

T Nilsson, B Norberg, O Rudolphi, L Jacobsson
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引用次数: 20

Abstract

The presence of 2 M-components in single patients (double gammopathy) was studied retrospectively by means of the electrophoresis files in Umeå (serving a population of approximately 150 000 inhabitants). During the 11-year period 1974-1984, 109 000 electrophoreses were performed, among which 1034 patients with gammopathy were found. Of these, 20 (2%) had double gammopathy; 3 were associated with lymphoma, 7 with myelomatosis, 9 with monoclonal gammopathy of undetermined significance (MGUS), and 1 with lupus erythematosus disseminatus. It is suggested that one subgroup of double gammopathy (6 patients) had a neoplastic cell clone combined with a normally regulated cell line, the latter marked by a transient M-component. Another subgroup (14 patients) seems to have 2 coexisting different neoplastic cell lines, with persistent double gammopathy.

双伽玛病:20例患者的发病率及临床病程。
在ume(服务于大约15万居民的人口),通过电泳档案回顾性地研究了单个患者(双伽马病)中2种m成分的存在。在1974-1984年的11年间,共进行了109000次电泳,其中发现1034例伽玛病。其中,20例(2%)患有双伽马病;3例与淋巴瘤相关,7例与骨髓瘤病相关,9例与意义不明的单克隆伽玛病(MGUS)相关,1例与广泛性红斑狼疮相关。这表明双伽马病的一个亚组(6例患者)有一个肿瘤细胞克隆与一个正常调节的细胞系结合,后者以短暂的m成分为特征。另一个亚组(14例)似乎有两种不同的肿瘤细胞系共存,并伴有持续的双伽玛病。
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