Caroline Rouard, Elisabeth Njamkepo, Marie-Laure Quilici, Scott Nguyen, Victoria Knight-Connoni, Renáta Šafránková, Francois-Xavier Weill
{"title":"<i>Vibrio cholerae</i> serogroup O5 was responsible for the outbreak of gastroenteritis in Czechoslovakia in 1965.","authors":"Caroline Rouard, Elisabeth Njamkepo, Marie-Laure Quilici, Scott Nguyen, Victoria Knight-Connoni, Renáta Šafránková, Francois-Xavier Weill","doi":"10.1099/mgen.0.001282","DOIUrl":null,"url":null,"abstract":"<p><p>Several authors have attributed the explosive outbreak of gastroenteritis that occurred in Czechoslovakia in 1965 to a toxigenic strain of <i>Vibrio cholerae</i> serogroup O37 based on unverified metadata associated with three particular strains from the American Type Culture Collection. Here, by sequencing the original strain preserved at the Czech National Collection of Type Cultures since 1966, we show that the strain responsible for this outbreak was actually a <i>V. cholerae</i> O5 that lacks the genes encoding the cholera toxin, the toxin-coregulated pilus protein and <i>Vibrio</i> pathogenicity islands present in <i>V. cholerae</i> O37 strains.</p>","PeriodicalId":18487,"journal":{"name":"Microbial Genomics","volume":null,"pages":null},"PeriodicalIF":4.0000,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Microbial Genomics","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1099/mgen.0.001282","RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GENETICS & HEREDITY","Score":null,"Total":0}
引用次数: 0
Abstract
Several authors have attributed the explosive outbreak of gastroenteritis that occurred in Czechoslovakia in 1965 to a toxigenic strain of Vibrio cholerae serogroup O37 based on unverified metadata associated with three particular strains from the American Type Culture Collection. Here, by sequencing the original strain preserved at the Czech National Collection of Type Cultures since 1966, we show that the strain responsible for this outbreak was actually a V. cholerae O5 that lacks the genes encoding the cholera toxin, the toxin-coregulated pilus protein and Vibrio pathogenicity islands present in V. cholerae O37 strains.
期刊介绍:
Microbial Genomics (MGen) is a fully open access, mandatory open data and peer-reviewed journal publishing high-profile original research on archaea, bacteria, microbial eukaryotes and viruses.