Vibrio cholerae serogroup O5 was responsible for the outbreak of gastroenteritis in Czechoslovakia in 1965.

IF 4 2区 生物学 Q1 GENETICS & HEREDITY
Caroline Rouard, Elisabeth Njamkepo, Marie-Laure Quilici, Scott Nguyen, Victoria Knight-Connoni, Renáta Šafránková, Francois-Xavier Weill
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引用次数: 0

Abstract

Several authors have attributed the explosive outbreak of gastroenteritis that occurred in Czechoslovakia in 1965 to a toxigenic strain of Vibrio cholerae serogroup O37 based on unverified metadata associated with three particular strains from the American Type Culture Collection. Here, by sequencing the original strain preserved at the Czech National Collection of Type Cultures since 1966, we show that the strain responsible for this outbreak was actually a V. cholerae O5 that lacks the genes encoding the cholera toxin, the toxin-coregulated pilus protein and Vibrio pathogenicity islands present in V. cholerae O37 strains.

O5 型霍乱弧菌血清群是 1965 年捷克斯洛伐克爆发肠胃炎的罪魁祸首。
一些作者根据美国模式培养物保藏中心(American Type Culture Collection)中与三个特定菌株相关的未经核实的元数据,将 1965 年在捷克斯洛伐克爆发的爆炸性肠胃炎疫情归因于 O37 血清群霍乱弧菌的毒力菌株。在这里,通过对自 1966 年以来保存在捷克国家类型培养物保藏中心的原始菌株进行测序,我们发现造成此次疫情的菌株实际上是霍乱弧菌 O5,它缺乏霍乱毒素编码基因、毒素调控柔毛蛋白和霍乱弧菌 O37 菌株中的致病性弧菌岛。
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来源期刊
Microbial Genomics
Microbial Genomics Medicine-Epidemiology
CiteScore
6.60
自引率
2.60%
发文量
153
审稿时长
12 weeks
期刊介绍: Microbial Genomics (MGen) is a fully open access, mandatory open data and peer-reviewed journal publishing high-profile original research on archaea, bacteria, microbial eukaryotes and viruses.
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