Advances in Technology for Melanoma Diagnosis and Prognosis: An Expert Consensus Panel.

IF 1.5 4区 医学 Q3 DERMATOLOGY
Joshua Burshtein, Danny Zakria, Milaan Shah, Brian Berman, Seemal R Desai, Aaron S Farberg, Gary Goldenberg, Brad Glick, Mark Nestor, Keyvan Nouri, Theodore Rosen, Mark Lebwohl, Darrell Rigel
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Abstract

Background: Cutaneous melanoma (CM) is associated with a higher mortality rate than most other skin cancers. The purpose of this expert consensus panel was to review the published literature on new technological advancements for the diagnosis and prognosis for CM and provide updated guidance on their usage.

Methods: A comprehensive literature search of PubMed, Scopus, and Google Scholar was completed for English-language original research articles on the topics of non-invasive diagnostic and prognostic testing for CM, including gene expression profiling (GEP) and electrical impedance spectroscopy (EIS). A panel of 10 dermatologists with significant expertise in the treatment of CM gathered to review the articles and create consensus statements. A modified Delphi process was used to approve each statement and a strength of recommendation was assigned using widely recognized Strength of Recommendation Taxonomy criteria.

Results: The literature search produced 200 articles that met the criteria. A screening of the studies resulted in 19 articles. These were distributed to all panelists for review prior to a roundtable discussion. The panel unanimously voted to adopt 7 consensus statements and recommendations, 5 of which were given a strength of "A", 1 of which was given a strength of "B," and 1 of which was given a strength of "C".

Conclusion: The 2-GEP test and EIS can aid in the precise diagnosis of clinically indeterminate lesions and the 23-GEP test can be used when histopathology is equivocal. The 31-GEP test can enhance prognostic assessment beyond AJCC8 staging and improve clinical decision-making. J Drugs Dermatol. 2024;23(9):774-781. doi:10.36849/JDD.8365R1.

黑色素瘤诊断和预后技术的进步:专家共识小组。
背景:皮肤黑色素瘤(CM)的死亡率高于其他大多数皮肤癌。本专家共识小组的目的是回顾已发表的有关用于诊断和预后皮肤黑色素瘤的新技术进展的文献,并就其使用提供最新指导:方法:在 PubMed、Scopus 和 Google Scholar 上对有关 CM 非侵入性诊断和预后检测(包括基因表达谱分析 (GEP) 和电阻抗光谱分析 (EIS))的英文原创研究文章进行了全面的文献检索。一个由 10 位在 CM 治疗方面具有丰富专业知识的皮肤科专家组成的小组对这些文章进行了审阅,并形成了共识声明。每份声明均采用修改后的德尔菲流程进行审批,并根据广受认可的推荐强度分类标准确定推荐强度:文献检索结果有 200 篇文章符合标准。对这些研究进行筛选后得出了 19 篇文章。在圆桌讨论之前,这些文章被分发给所有小组成员审阅。专家小组一致投票通过了 7 项共识声明和建议,其中 5 项为 "A "级,1 项为 "B "级,1 项为 "C "级:结论:2-GEP 试验和 EIS 可以帮助精确诊断临床上不确定的病变,23-GEP 试验可用于组织病理学不明确的情况。31-GEP测试可加强AJCC8分期以外的预后评估,并改善临床决策。J Drugs Dermatol.2024;23(9):774-781. doi:10.36849/JDD.8365R1.
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来源期刊
CiteScore
2.20
自引率
13.30%
发文量
289
审稿时长
3-6 weeks
期刊介绍: The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.
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