A Clinical Histology Study Evaluating the Biostimulatory Activity Longevity of Injectable Poly-L-Lactic Acid for Facial Rejuvenation.

IF 1.5 4区医学 Q3 DERMATOLOGY

Journal of Drugs in Dermatology Pub Date : 2024-09-01 DOI:10.36849/JDD.8057

Suleima Arruda, Victor Prieto, Christopher Shea, Alyssa Swearingen, Zahyaa Elmadany, Neil S Sadick

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引用次数: 0

Abstract

Background: Poly-L-lactic acid (PLLA) is an injectable filler used for restoring facial fat volume loss that improves skin quality.

Objective: To evaluate the histological changes underlying the observed improvement in skin quality after repeated PLLA injections.

Methods: Ten healthy women were enrolled in this randomized, placebo-controlled, single-center study. Eligible subjects received 3 treatments every 4 weeks with either PLLA (treatment group) or saline (control group) injections, into both sides of the face. Follow-up visits were at week 18 after the last treatment. Assessments included live ratings, patient questionnaires, three-dimensional microtopography imaging analysis, and histological analysis from biopsies taken before and after PLLA treatment.

Results: At the 18-week follow-up, there was a significant improvement in investigator- and subject-rated global aesthetic improvement (GAIS) scores, as well as a decrease in wrinkle severity in PLLA-treated but not placebo-treated patients. Skin quality parameters of erythema, pore size, and roughness were significantly improved from baseline and compared with placebo at the 18-week follow-up as assessed by microtopographic analysis and investigator ratings. Histologic analysis revealed increased tissue remodeling and angiogenesis in PLLA-treated tissues at the 18-week follow-up and decreased elastin fragmentation compared with baseline. No treatment-related adverse events occurred.

Conclusion: Repeated PLLA treatments may improve skin quality through tissue remodeling and neovascularization. J Drugs Dermatol. 2024;23(9):729-734. doi:10.36849/JDD.8057.

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一项临床组织学研究，评估用于面部年轻化的注射用聚乳酸的生物刺激活性寿命。

背景：聚左旋乳酸（PLLA）是一种可注射填充物，用于恢复面部脂肪流失，改善皮肤质量：聚左旋乳酸（PLLA）是一种可注射的填充物，用于恢复面部脂肪流失，改善皮肤质量：评估反复注射聚乳酸后观察到的皮肤质量改善背后的组织学变化：十名健康女性参加了这项随机、安慰剂对照、单中心研究。符合条件的受试者每 4 周接受 3 次治疗，在面部两侧注射 PLLA（治疗组）或生理盐水（对照组）。在最后一次治疗后的第 18 周进行随访。评估包括现场评分、患者问卷调查、三维微切片成像分析以及 PLLA 治疗前后活组织切片的组织学分析：结果：在18周的随访中，接受过PLLA治疗而未接受过安慰剂治疗的患者在研究者和受试者评定的整体美学改善（GAIS）评分方面均有显著改善，皱纹严重程度也有所下降。根据微观表层分析和研究人员的评分，在 18 周的随访中，红斑、毛孔大小和粗糙度等皮肤质量参数与基线相比有了明显改善，与安慰剂相比也有了明显改善。组织学分析表明，在 18 周的随访中，PLLA 治疗组织中的组织重塑和血管生成增加，弹性蛋白碎片与基线相比减少。没有发生与治疗相关的不良事件：结论：重复 PLLA 治疗可通过组织重塑和血管新生改善皮肤质量。J Drugs Dermatol.2024;23(9):729-734. doi:10.36849/JDD.8057.

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来源期刊

Journal of Drugs in Dermatology DERMATOLOGY-

CiteScore

2.20

自引率

13.30%

发文量

289

审稿时长

3-6 weeks

期刊介绍： The Journal of Drugs in Dermatology (JDD) is a peer-reviewed publication indexed with MEDLINE®/PubMed® that was founded by the renowned Dr. Perry Robins MD. Founded in 2002, it offers one of the fastest routes to disseminate dermatologic information and is considered the fastest growing publication in dermatology. We present original articles, award-winning case reports, and timely features pertaining to new methods, techniques, drug therapy, and devices in dermatology that provide readers with peer reviewed content of the utmost quality. Our high standards of content are maintained through a balanced, peer-review process. Articles are reviewed by an International Editorial Board of over 160 renowned experts.