Cancer immunotherapy of Wilms tumor: a narrative review.

IF 3 4区 医学 Q2 ONCOLOGY
Future oncology Pub Date : 2024-01-01 Epub Date: 2024-09-05 DOI:10.1080/14796694.2024.2386929
Yu Lin He, Jin Yan Liu, Rahma Taher Almgrami, Ying Zhong Fan, Yi Zhang
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引用次数: 0

Abstract

Wilms tumor (WT) is the most common malignant tumor of the urinary system in children. Though the traditional treatment of surgery plus radiotherapy and chemotherapy achieves exciting clinical efficacy, in relapsed and refractory cases, the long-term overall survival rates are poor. Besides, chemotherapy and radiation have serious long-term toxic side effects on children. Cancer immunotherapy is a new tumor therapy that works by activating the body's immune system to allow immune cells to kill tumor cells more efficiently. Currently, cancer immunotherapy has been tested in clinical trials or basic studies in WT. This article reviews the current status of clinical trials and basic research of cancer immunotherapy in WT to promote the application of cancer immunotherapy in WT patients.

Wilms 肿瘤的癌症免疫疗法:综述。
Wilms 肿瘤(WT)是儿童泌尿系统最常见的恶性肿瘤。虽然传统的手术加放疗和化疗的治疗方法取得了令人振奋的临床疗效,但对于复发和难治性病例,长期总生存率较低。此外,化疗和放疗对儿童有严重的长期毒副作用。癌症免疫疗法是一种新型的肿瘤治疗方法,它通过激活人体的免疫系统,让免疫细胞更有效地杀死肿瘤细胞。目前,癌症免疫疗法已在 WT 进行了临床试验或基础研究。本文回顾了癌症免疫疗法在WT中的临床试验和基础研究现状,以促进癌症免疫疗法在WT患者中的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Future oncology
Future oncology ONCOLOGY-
CiteScore
5.40
自引率
3.00%
发文量
335
审稿时长
4-8 weeks
期刊介绍: Future Oncology (ISSN 1479-6694) provides a forum for a new era of cancer care. The journal focuses on the most important advances and highlights their relevance in the clinical setting. Furthermore, Future Oncology delivers essential information in concise, at-a-glance article formats - vital in delivering information to an increasingly time-constrained community. The journal takes a forward-looking stance toward the scientific and clinical issues, together with the economic and policy issues that confront us in this new era of cancer care. The journal includes literature awareness such as the latest developments in radiotherapy and immunotherapy, concise commentary and analysis, and full review articles all of which provide key findings, translational to the clinical setting.
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