The miRNA Landscape in Crohn's disease: Implications for novel therapeutic approaches and interactions with Existing therapies

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Experimental cell research Pub Date : 2024-09-02 DOI:10.1016/j.yexcr.2024.114234

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引用次数: 0

Abstract

MicroRNAs (miRNAs), which are non-coding RNAs consisting of 18–24 nucleotides, play a crucial role in the regulatory pathways of inflammatory diseases. Several recent investigations have examined the potential role of miRNAs in forming Crohn's disease (CD). It has been suggested that miRNAs serve as diagnostics for both fibrosis and inflammation in CD due to their involvement in the mechanisms of CD aggravation and fibrogenesis. More information on CD pathophysiology could be obtained by identifying the miRNAs concerned with CD and their target genes. These findings have prompted several in vitro and in vivo investigations into the putative function of miRNAs in CD treatment. Although there are still many unanswered questions, the growing body of evidence has brought miRNA-based therapy one step closer to clinical practice. This extensive narrative study offers a concise summary of the most current advancements in CD. We go over what is known about the diagnostic and therapeutic benefits of miRNA mimicry and inhibition so far, and we see what additional miRNA family targets could be useful for treating CD-related inflammation and fibrosis.

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克罗恩病的 miRNA 图谱：新治疗方法的意义以及与现有疗法的相互作用。

微小RNA（miRNA）是由18-24个核苷酸组成的非编码RNA，在炎症性疾病的调控途径中发挥着至关重要的作用。最近的一些研究探讨了 miRNA 在克罗恩病（CD）形成过程中的潜在作用。有研究认为，由于 miRNAs 参与了克罗恩病（CD）的恶化和纤维化机制，因此可作为克罗恩病纤维化和炎症的诊断指标。通过鉴定与 CD 有关的 miRNA 及其靶基因，可以获得更多有关 CD 病理生理学的信息。这些发现促使人们对 miRNA 在 CD 治疗中的假定功能进行了多项体外和体内研究。尽管仍有许多未解之谜，但越来越多的证据已使基于 miRNA 的疗法离临床实践更近了一步。这项内容广泛的叙述性研究简明扼要地总结了 CD 领域的最新进展。我们回顾了目前已知的 miRNA 模拟和抑制对诊断和治疗的益处，并了解了还有哪些 miRNA 家族靶点可用于治疗 CD 相关炎症和纤维化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental cell research 医学-细胞生物学

CiteScore

7.20

自引率

0.00%

发文量

295

审稿时长

30 days

期刊介绍： Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.