{"title":"Isolation of isosecotanapartholide from Artemisia vulgaris L. as potential insecticide against stored grain insect pests and it's in silico studies","authors":"","doi":"10.1016/j.aoas.2024.08.001","DOIUrl":null,"url":null,"abstract":"<div><p>There is a constant search for safer, eco-friendly and effective insect control agent alternatives of natural origin due to concerns in human health, ecology and development of insect resistance to conventional chemical insecticides. Accordingly, a fumigant molecule, isosecotanapartholide (ISTP) from <em>Artemisia vulgaris</em> L., has been isolated and characterized following laboratory bioassays against stored grain insect pests. Physicochemical and spectroscopic analyses correlated with literature data to yield the structure of ISTP, a volatile organic compound. The isolated organic compound is highly toxic to adults of <em>Sitophilus oryzae</em> (L.), <em>Tribolium castaneum</em> (Herbst.) and <em>Corcyra cephalonica</em> (Stainton) with LC<sub>50</sub> values of 1.82, 2.19 and 1.83 μg/L respectively. ISTP also exhibits potent acetylcholinesterase (AChE) inhibitor activity <em>in vivo</em> and <em>in vitro</em> analysis. Additionally, molecular docking and molecular dynamics simulation analysis provide insight into the possible interaction between ISTP and AChE of <em>S. oryzae</em>, without any adverse effect on seed germination. In summary, ISTP from <em>A. vulgaris</em> source is a potential insecticide against stored grain insect pests and alternative to synthetic pesticides.</p></div>","PeriodicalId":54198,"journal":{"name":"Annals of Agricultural Science","volume":null,"pages":null},"PeriodicalIF":3.5000,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0570178324000083/pdfft?md5=81ca56413acd2888945ccad7226765c8&pid=1-s2.0-S0570178324000083-main.pdf","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Agricultural Science","FirstCategoryId":"97","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0570178324000083","RegionNum":2,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"AGRICULTURE, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
There is a constant search for safer, eco-friendly and effective insect control agent alternatives of natural origin due to concerns in human health, ecology and development of insect resistance to conventional chemical insecticides. Accordingly, a fumigant molecule, isosecotanapartholide (ISTP) from Artemisia vulgaris L., has been isolated and characterized following laboratory bioassays against stored grain insect pests. Physicochemical and spectroscopic analyses correlated with literature data to yield the structure of ISTP, a volatile organic compound. The isolated organic compound is highly toxic to adults of Sitophilus oryzae (L.), Tribolium castaneum (Herbst.) and Corcyra cephalonica (Stainton) with LC50 values of 1.82, 2.19 and 1.83 μg/L respectively. ISTP also exhibits potent acetylcholinesterase (AChE) inhibitor activity in vivo and in vitro analysis. Additionally, molecular docking and molecular dynamics simulation analysis provide insight into the possible interaction between ISTP and AChE of S. oryzae, without any adverse effect on seed germination. In summary, ISTP from A. vulgaris source is a potential insecticide against stored grain insect pests and alternative to synthetic pesticides.
期刊介绍:
Annals of Agricultural Sciences (AOAS) is the official journal of Faculty of Agriculture, Ain Shams University. AOAS is an open access peer-reviewed journal publishing original research articles and review articles on experimental and modelling research at laboratory, field, farm, landscape, and industrial levels. AOAS aims to maximize the quality of the agricultural sector across the globe with emphasis on the Arabian countries by focusing on publishing the high-quality applicable researches, in addition to the new methods and frontiers leading to maximizing the quality and quantity of both plant and animal yield and final products.