Isolation of isosecotanapartholide from Artemisia vulgaris L. as potential insecticide against stored grain insect pests and it's in silico studies

IF 3.5 2区 农林科学 Q1 AGRICULTURE, MULTIDISCIPLINARY
Nameirakpam B. Singh , Shankarrao Patil , Kabrambam D. Singh , Jharna Chakravorty , Suresh B. Katragadda , Bandi Siva , Pulok K. Mukherjee , Yallappa Rajashekar
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引用次数: 0

Abstract

There is a constant search for safer, eco-friendly and effective insect control agent alternatives of natural origin due to concerns in human health, ecology and development of insect resistance to conventional chemical insecticides. Accordingly, a fumigant molecule, isosecotanapartholide (ISTP) from Artemisia vulgaris L., has been isolated and characterized following laboratory bioassays against stored grain insect pests. Physicochemical and spectroscopic analyses correlated with literature data to yield the structure of ISTP, a volatile organic compound. The isolated organic compound is highly toxic to adults of Sitophilus oryzae (L.), Tribolium castaneum (Herbst.) and Corcyra cephalonica (Stainton) with LC50 values of 1.82, 2.19 and 1.83 μg/L respectively. ISTP also exhibits potent acetylcholinesterase (AChE) inhibitor activity in vivo and in vitro analysis. Additionally, molecular docking and molecular dynamics simulation analysis provide insight into the possible interaction between ISTP and AChE of S. oryzae, without any adverse effect on seed germination. In summary, ISTP from A. vulgaris source is a potential insecticide against stored grain insect pests and alternative to synthetic pesticides.

从蒿属植物中分离出异苏木内酯,作为潜在的杀虫剂防治储粮害虫及其硅学研究
由于对人类健康、生态和昆虫对传统化学杀虫剂产生抗药性的担忧,人们一直在寻找更安全、环保和有效的天然昆虫控制剂替代品。因此,在对贮藏谷物害虫进行实验室生物测定后,我们分离并鉴定了一种熏蒸剂分子,即来自茵陈蒿(Artemisia vulgaris L.)的异苏木内酯(isosecotanapartholide,ISTP)。理化分析和光谱分析与文献数据相关,得出了 ISTP 的结构,它是一种挥发性有机化合物。分离出的有机化合物对 Sitophilus oryzae (L.)、Tribolium castaneum (Herbst.) 和 Corcyra cephalonica (Stainton) 的成虫有剧毒,半数致死浓度分别为 1.82、2.19 和 1.83 微克/升。在体内和体外分析中,ISTP 还表现出强效的乙酰胆碱酯酶(AChE)抑制剂活性。此外,分子对接和分子动力学模拟分析还揭示了 ISTP 与 S. oryzae 的乙酰胆碱酯酶之间可能存在的相互作用,而且不会对种子萌发产生任何不利影响。总之,从 A. vulgaris 源中提取的 ISTP 是一种潜在的杀虫剂,可用于防治储粮害虫,是合成杀虫剂的替代品。
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来源期刊
Annals of Agricultural Science
Annals of Agricultural Science AGRICULTURE, MULTIDISCIPLINARY-
CiteScore
12.60
自引率
0.00%
发文量
18
审稿时长
33 days
期刊介绍: Annals of Agricultural Sciences (AOAS) is the official journal of Faculty of Agriculture, Ain Shams University. AOAS is an open access peer-reviewed journal publishing original research articles and review articles on experimental and modelling research at laboratory, field, farm, landscape, and industrial levels. AOAS aims to maximize the quality of the agricultural sector across the globe with emphasis on the Arabian countries by focusing on publishing the high-quality applicable researches, in addition to the new methods and frontiers leading to maximizing the quality and quantity of both plant and animal yield and final products.
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