Insights into RNA N6-methyladenosine and programmed cell death in atherosclerosis.

IF 6 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Haijiao Long, Yulu Yu, Jie Ouyang, Hongwei Lu, Guojun Zhao
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引用次数: 0

Abstract

N6-methyladenosine (m6A) modification stands out among various RNA modifications as the predominant form within eukaryotic cells, influencing numerous cellular processes implicated in disease development. m6A modification has gained increasing attention in the development of atherosclerosis and has become a research hotspot in recent years. Programmed cell death (PCD), encompassing apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis, plays a pivotal role in atherosclerosis pathogenesis. In this review, we delve into the intricate interplay between m6A modification and diverse PCD pathways, shedding light on their complex association during the onset and progression of atherosclerosis. Clarifying the relationship between m6A and PCD in atherosclerosis is of great significance to provide novel strategies for cardiovascular disease treatment.

透视动脉粥样硬化中的 RNA N6-甲基腺苷和程序性细胞死亡
N6-甲基腺苷(m6A)修饰是真核细胞内各种 RNA 修饰的主要形式,影响着许多与疾病发展有关的细胞过程。m6A 修饰在动脉粥样硬化的发展过程中日益受到关注,近年来已成为研究热点。程序性细胞死亡(PCD)包括细胞凋亡、自噬、热凋亡、铁凋亡和坏死,在动脉粥样硬化发病机制中起着关键作用。在这篇综述中,我们将深入探讨 m6A 修饰与多种 PCD 途径之间错综复杂的相互作用,揭示它们在动脉粥样硬化发生和发展过程中的复杂关联。厘清动脉粥样硬化中 m6A 与 PCD 的关系对于提供治疗心血管疾病的新策略具有重要意义。
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来源期刊
Molecular Medicine
Molecular Medicine 医学-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
137
审稿时长
1 months
期刊介绍: Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.
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