Survival among patients cured from gastric adenocarcinoma compared to the background population.

IF 6 1区 医学 Q1 GASTROENTEROLOGY & HEPATOLOGY
Gastric Cancer Pub Date : 2024-11-01 Epub Date: 2024-09-04 DOI:10.1007/s10120-024-01545-y
Wilhelm Leijonmarck, Fredrik Mattsson, Jesper Lagergren
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引用次数: 0

Abstract

Background: It is unknown if gastric adenocarcinoma survivors have longer, shorter, or similar survival compared to the background population. This knowledge could contribute to evidence-based monitoring strategies, healthcare recommendations, and information for patients and families.

Methods: This population-based cohort study included all patients who underwent gastrectomy for gastric adenocarcinoma between 2006-2015 in Sweden and survived ≥ 5 years after surgery. They were followed up until death, postoperative year 10, or end of study period (31 December, 2020). Division of the observed by the expected survival yielded relative survival rates with 95% confidence intervals (CIs) using the life table method. The expected survival was derived from the entire Swedish population of the corresponding age, sex, and calendar year. Data came from medical records and nationwide registers.

Results: The survival among all 767 gastric adenocarcinoma survivors was shorter than the expected. The reduction in relative survival increased for each follow-up year, from 97.3% (95% CI 95.4-99.1%) year 6 to 86.6% (95% CI 82.3-90.9%) year 10. The decline in relative survival was more pronounced among patients who had gastrectomy in earlier calendar years (82.9% [95% CI 77.4-88.4%] year 10 for years 2011-2015), shorter education (85.2% [95% CI 77.4-93.0%] year 10 for education ≤ 9 years), more comorbidities (78.0% [95% CI 63.9-92.0%] year 10 for Charlson comorbidity score ≥ 2), and no neoadjuvant therapy (83.2% [95% CI 77.4-89.0%] year 10).

Conclusion: Gastric adenocarcinoma survivors seem to have poorer survival than the corresponding background population, particularly in certain subgroups.

Abstract Image

与背景人群相比,胃腺癌治愈患者的生存率。
背景:胃腺癌幸存者的存活期与背景人群相比是更长、更短还是相似,目前尚不清楚。这方面的知识有助于制定循证监测策略、医疗保健建议以及为患者和家属提供信息:这项基于人群的队列研究纳入了 2006-2015 年间瑞典所有因胃腺癌接受胃切除术且术后存活≥ 5 年的患者。对他们进行了随访,直至死亡、术后第 10 年或研究期结束(2020 年 12 月 31 日)。用生命表法将观察存活率除以预期存活率得出相对存活率及 95% 置信区间 (CI)。预期存活率是根据相应年龄、性别和日历年的整个瑞典人口得出的。数据来自医疗记录和全国范围的登记:结果:所有 767 名胃腺癌幸存者的存活率均低于预期存活率。相对存活率的下降幅度随着随访年份的增加而增加,从第6年的97.3%(95% CI 95.4-99.1%)下降到第10年的86.6%(95% CI 82.3-90.9%)。相对生存率的下降在较早日历年(2011-2015 年,第 10 年为 82.9% [95% CI 77.4-88.4%])、受教育程度较低(2011-2015 年,受教育程度 ≥ 95% 的第 10 年为 85.2% [95% CI 77.4-93.0%])的患者中更为明显。0%],合并症较多(Charlson合并症评分≥2的第10年为78.0%[95% CI 63.9-92.0%]),未进行新辅助治疗(第10年为83.2%[95% CI 77.4-89.0%]):结论:胃腺癌幸存者的生存率似乎低于相应的背景人群,尤其是在某些亚组中。
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来源期刊
Gastric Cancer
Gastric Cancer 医学-胃肠肝病学
CiteScore
14.70
自引率
2.70%
发文量
80
审稿时长
6-12 weeks
期刊介绍: Gastric Cancer is an esteemed global forum that focuses on various aspects of gastric cancer research, treatment, and biology worldwide. The journal promotes a diverse range of content, including original articles, case reports, short communications, and technical notes. It also welcomes Letters to the Editor discussing published articles or sharing viewpoints on gastric cancer topics. Review articles are predominantly sought after by the Editor, ensuring comprehensive coverage of the field. With a dedicated and knowledgeable editorial team, the journal is committed to providing exceptional support and ensuring high levels of author satisfaction. In fact, over 90% of published authors have expressed their intent to publish again in our esteemed journal.
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