Molecular Activities and Mechanisms of Action of Substances and Molecules from Medicinal Plants from Sub-Saharan Africa on Prostate and Cervical Cancer Cells.

IF 2.6 4区医学 Q3 CHEMISTRY, MEDICINAL

Anti-cancer agents in medicinal chemistry Pub Date : 2024-09-03 DOI:10.2174/0118715206321859240827045546

Liz Laetitia Coulibaly, Bagora Bayala, Jacques Simpore

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引用次数: 0

Abstract

Background: Despite years of medical research, cancer remains a major public health problem worldwide, particularly in Africa. The cost, duration, and toxicity of currently available treatments are all drawbacks. Plant secondary metabolites are significant anticancer compounds. Already used in traditional health systems, plants are currently the subject of numerous studies to discover new anti-cancer drugs.

Objective: This review assesses the literature on the cytotoxic effect of plant substances (extracts) and molecules on prostate and cervical cancer cell lines.

Method: PubMed, Science Direct, and Google Scholar were used to find in vitro studies carried out between 2006 and 2023 related to the cytotoxicity of extracts, substances and/or molecules from plants harvested in sub-Saharan Africa against prostate and/or cervical cancer cell lines.

Results: A total of 36 reports on the cytotoxic potential of 96 medicinal plants from sub-Saharan Africa were extracted from the selected databases. All the plants listed had a cytotoxic effect on prostate and/or cervical cancer cells. Some plant extracts or molecules showed significant activity with an IC50< 20 μg/ml. Burkina Faso and South Africa had the most plant extracts tested for prostate and cervical cancer, respectively.

Conclusion: A total of 36 reports on the cytotoxic potential of 96 medicinal plants from sub-Saharan Africa were extracted from the selected databases.

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撒哈拉以南非洲药用植物中的物质和分子对前列腺癌和宫颈癌细胞的分子活性和作用机制。

背景：尽管经过多年的医学研究，癌症仍然是全世界，尤其是非洲的一个主要公共卫生问题。现有治疗方法的成本、持续时间和毒性都是其缺点。植物次生代谢物是重要的抗癌化合物。植物已被用于传统保健系统，目前正在进行大量研究，以发现新的抗癌药物：本综述评估了有关植物物质（提取物）和分子对前列腺癌和宫颈癌细胞系的细胞毒性作用的文献：方法：使用 PubMed、Science Direct 和 Google Scholar 查找 2006 年至 2023 年期间进行的有关撒哈拉以南非洲地区收获的植物提取物、物质和/或分子对前列腺癌和/或宫颈癌细胞系的细胞毒性的体外研究：结果：从所选数据库中共提取了 36 份关于撒哈拉以南非洲地区 96 种药用植物细胞毒性潜力的报告。所有列出的植物都对前列腺癌和/或宫颈癌细胞有细胞毒性作用。一些植物提取物或分子显示出显著的活性，IC50< 20 μg/ml。布基纳法索和南非的植物提取物对前列腺癌和宫颈癌的测试次数分别最多：结论：从选定的数据库中共提取了 36 份关于撒哈拉以南非洲地区 96 种药用植物细胞毒性潜力的报告。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Anti-cancer agents in medicinal chemistry ONCOLOGY-CHEMISTRY, MEDICINAL

CiteScore

5.10

自引率

3.60%

发文量

323

审稿时长

4-8 weeks

期刊介绍： Formerly: Current Medicinal Chemistry - Anti-Cancer Agents. Anti-Cancer Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of anti-cancer agents. Each issue contains a series of timely in-depth reviews and guest edited issues written by leaders in the field covering a range of current topics in cancer medicinal chemistry. The journal only considers high quality research papers for publication. Anti-Cancer Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in cancer drug discovery.