Analysis of ductal carcinoma in situ by self-reported race reveals molecular differences related to outcome.

IF 7.4 1区医学 Q1 Medicine

Breast Cancer Research Pub Date : 2024-09-02 DOI:10.1186/s13058-024-01885-8

Siri H Strand, Kathleen E Houlahan, Vernal Branch, Thomas Lynch, Belén Rivero-Guitiérrez, Bryan Harmon, Fergus Couch, Kristalyn Gallagher, Mark Kilgore, Shi Wei, Angela DeMichele, Tari King, Priscilla McAuliffe, Christina Curtis, Kouros Owzar, Jeffrey R Marks, Graham A Colditz, E Shelley Hwang, Robert B West

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引用次数: 0

Abstract

Background: Ductal carcinoma in situ (DCIS) is a non-obligate precursor to invasive breast cancer (IBC). Studies have indicated differences in DCIS outcome based on race or ethnicity, but molecular differences have not been investigated.

Methods: We examined the molecular profile of DCIS by self-reported race (SRR) and outcome groups in Black (n = 99) and White (n = 191) women in a large DCIS case-control cohort study with longitudinal follow up.

Results: Gene expression and pathway analyses suggested that different genes and pathways are involved in diagnosis and ipsilateral breast outcome (DCIS or IBC) after DCIS treatment in White versus Black women. We identified differences in ER and HER2 expression, tumor microenvironment composition, and copy number variations by SRR and outcome groups.

Conclusions: Our results suggest that different molecular mechanisms drive initiation and subsequent ipsilateral breast events in Black versus White women.

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按自我报告的种族对乳腺导管原位癌进行分析，发现了与预后有关的分子差异。

背景：乳腺导管原位癌（DCIS）是浸润性乳腺癌（IBC）的非致病前体。研究表明，不同种族或族裔的 DCIS 结果存在差异，但尚未对分子差异进行调查：方法：在一项大型 DCIS 病例对照队列研究中，我们按自我报告的种族（SRR）和结果组别对黑人（n = 99）和白人（n = 191）妇女的 DCIS 分子特征进行了研究，并进行了纵向随访：基因表达和通路分析表明，白人妇女与黑人妇女在DCIS治疗后的诊断和同侧乳腺结果（DCIS或IBC）中存在不同的基因和通路。我们发现了ER和HER2表达、肿瘤微环境组成以及拷贝数变异在SRR和结果组中的差异：我们的研究结果表明，不同的分子机制驱动着黑人妇女与白人妇女的乳腺癌发病和随后的同侧乳腺癌事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Breast Cancer Research ONCOLOGY-

CiteScore

12.00

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Breast Cancer Research, an international, peer-reviewed online journal, publishes original research, reviews, editorials, and reports. It features open-access research articles of exceptional interest across all areas of biology and medicine relevant to breast cancer. This includes normal mammary gland biology, with a special emphasis on the genetic, biochemical, and cellular basis of breast cancer. In addition to basic research, the journal covers preclinical, translational, and clinical studies with a biological basis, including Phase I and Phase II trials.