Incretin hormone agonists: Current and emerging pharmacotherapy for obesity management.

IF 2.9 3区 医学 Q2 PHARMACOLOGY & PHARMACY
Pharmacotherapy Pub Date : 2024-09-01 Epub Date: 2024-09-03 DOI:10.1002/phar.4607
Ibrahim S Alhomoud, Azita H Talasaz, Preethi Chandrasekaran, Roy Brown, Anurag Mehta, Dave L Dixon
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引用次数: 0

Abstract

Obesity continues to be a significant global health challenge, affecting over 800 million individuals worldwide. Traditional management strategies, including dietary, exercise, and behavioral interventions, often result in insufficient and unsustainable weight loss. Lifestyle modification remains the cornerstone of obesity management, providing the foundation for other strategies. While options such as bariatric surgery remain an effective intervention for severe obesity, it is associated with its own set of risks and is typically reserved for patients who have not achieved the desired results with pharmacotherapy and lifestyle interventions. Incretin hormone agonists represent a significant advancement in the pharmacotherapy of obesity, offering substantial weight reduction and cardiometabolic benefits. Agents like liraglutide, semaglutide, and tirzepatide supported by key clinical trials such as Satiety and Clinical Adipose Liraglutide Evidence (SCALE), Semaglutide Treatment Effect in People with Obesity (STEP) program trials, and Tirzepatide Once Weekly for the Treatment of Obesity (SURMOUNT-1) have demonstrated remarkable efficacy in promoting weight loss and improving metabolic outcomes. Additionally, novel therapies, including dual and triple incretin agonists, are under investigation and hold the potential for further advancements in obesity treatment. These novel therapies can be categorized by their mechanisms of action and route of administration into oral glucagon-like peptide-1 (GLP-1) receptor agonists, triple agonists (targeting GLP-1, glucose-dependent insulinotropic polypeptide [GIP], and glucagon receptors), and glucagon receptor-GLP-1 receptor co-agonists. Other innovative approaches include oral GIP-GLP-1 receptor co-agonists, and the combination of long-acting amylin receptor agonists with GLP-1 receptor agonists. The ongoing development of incretin-based therapies and the expanding availability of currently available agents are expected to enhance clinical outcomes further and reduce the burden of obesity-related health complications. This review aims to discuss the mechanisms and efficacy of current and emerging incretin hormone agonists for obesity management.

内分泌激素激动剂:当前和新兴的肥胖症控制药物疗法。
肥胖症仍然是一项重大的全球健康挑战,影响着全球 8 亿多人。传统的管理策略,包括饮食、运动和行为干预,往往导致体重减轻不足和不可持续。改变生活方式仍然是肥胖症控制的基石,为其他策略奠定了基础。虽然减肥手术等方法仍是治疗严重肥胖症的有效干预措施,但它也有一定的风险,通常只适用于药物治疗和生活方式干预未达到预期效果的患者。胰岛素激素激动剂是肥胖症药物疗法的一大进步,能显著减轻体重并改善心脏代谢。利拉鲁肽、塞马鲁肽和替泽帕肽等药物在 "饱腹感和临床脂肪利拉鲁肽证据(SCALE)"、"塞马鲁肽对肥胖症患者的治疗效果(STEP)"和 "每周一次治疗肥胖症的替泽帕肽(SURMOUNT-1)"等重要临床试验的支持下,在促进体重减轻和改善代谢结果方面表现出显著疗效。此外,包括双重和三重增量素激动剂在内的新型疗法也在研究之中,有望进一步推动肥胖症的治疗。这些新型疗法可按其作用机制和给药途径分为口服胰高血糖素样肽-1(GLP-1)受体激动剂、三重激动剂(靶向 GLP-1、葡萄糖依赖性促胰岛素多肽 [GIP] 和胰高血糖素受体)以及胰高血糖素受体-GLP-1 受体联合激动剂。其他创新方法包括口服 GIP-GLP-1 受体联合受体激动剂,以及长效淀粉受体激动剂与 GLP-1 受体激动剂的联合应用。随着增量素疗法的不断发展以及现有药物供应的不断扩大,有望进一步提高临床疗效,减轻肥胖相关并发症的负担。本综述旨在讨论当前和新出现的增量素激素激动剂治疗肥胖症的机制和疗效。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Pharmacotherapy
Pharmacotherapy 医学-药学
CiteScore
7.80
自引率
2.40%
发文量
93
审稿时长
4-8 weeks
期刊介绍: Pharmacotherapy is devoted to publication of original research articles on all aspects of human pharmacology and review articles on drugs and drug therapy. The Editors and Editorial Board invite original research reports on pharmacokinetic, bioavailability, and drug interaction studies, clinical trials, investigations of specific pharmacological properties of drugs, and related topics.
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