Effect of Acupoint Catgut Embedding at Yanglingquan (GB34) on the Bile Metabolism of Patients with Choledocholithiasis after Surgery.

IF 0.9 Q4 INTEGRATIVE & COMPLEMENTARY MEDICINE
Lei Li, Xiaofan Ji, Xiaoyong Rao, Dewei Luo, Qiping Mao, Hui Du, Haihong Fang, Hui Ouyang, Yuan Zhang
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引用次数: 0

Abstract

Importance: Choledocholithiasis, or bile duct gallstones, is effectively treated with surgery, which does not prevent relapse. A common adjuvant therapy is the stimulation of the Yanglingquan point (GB34). Acupoint catgut embedding (ACE), an acupoint stimulation therapy, may be a better treatment for choledocholithiasis.

Objectives: To investigate the effect of ACE in stimulating GB34 on bile metabolism and its possible mechanism via metabonomics.

Methods: In this study, we used ultrahigh performance liquid chromatographyquadrupole time-of-flight mass spectrometry (UHPLC-MS/MS) to analyze the changes in bile metabolites, metabolic pathways, and liver function indicators in 16 patients with choledocholithiasis before and after ACE stimulation.

Results: We identified 10 metabolites that exhibited significant differences in the bile before and after ACE, six of which significantly increased and four that significantly decreased. Moreover, six liver function indicators showed a downward trend. We identified related metabolic pathways as glycerophospholipid metabolism, steroid biosynthesis, and the citrate cycle (TCA cycle).

Conclusions and relevance: This study shows that ACE stimulation of GB34 can effectively help treat choledocholithiasis, which may be clinically applicable to ACE.

阳陵泉(GB34)穴位埋线对胆总管结石患者术后胆汁代谢的影响
重要性:胆总管结石或胆管胆结石的有效治疗方法是手术,但手术并不能防止复发。常用的辅助疗法是刺激阳陵泉穴(GB34)。穴位猫肠埋(ACE)是一种穴位刺激疗法,可能是治疗胆总管结石的更好方法:通过代谢组学研究ACE刺激GB34对胆汁代谢的影响及其可能的机制:本研究采用超高效液相色谱-四极杆飞行时间质谱(UHPLC-MS/MS)分析了16例胆总管结石患者在ACE刺激前后胆汁代谢物、代谢途径和肝功能指标的变化:我们发现 10 种代谢物在 ACE 前后的胆汁中表现出显著差异,其中 6 种显著增加,4 种显著减少。此外,六项肝功能指标呈下降趋势。我们确定了甘油磷脂代谢、类固醇生物合成和柠檬酸循环(TCA 循环)等相关代谢途径:本研究表明,ACE 刺激 GB34 可有效帮助治疗胆总管结石,这可能适用于 ACE 的临床治疗。
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来源期刊
Journal of Acupuncture and Meridian Studies
Journal of Acupuncture and Meridian Studies INTEGRATIVE & COMPLEMENTARY MEDICINE-
CiteScore
1.50
自引率
10.00%
发文量
35
审稿时长
12 weeks
期刊介绍: The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine. Manuscripts should fall into one of the categories: topical review, original research paper, brief ... click here for full Aims & Scope The Journal of Acupuncture and Meridian Studies is a quarterly, peer-reviewed journal featuring high-quality studies related to basic and clinical acupuncture and meridian research. It also includes new paradigm of integrative research, covering East–West and traditional–modern medicine.
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