Association between eosinophilia and lymphocytosis with functional outcomes of patients with Hirschsprung disease following transabdominal Yancey-Soave pull-through.

Q3 Medicine

Medical Journal of Malaysia Pub Date : 2024-08-01

A N Zakiyah, K R Prasetyo, I Puspitawati, A Makhmudi, Gunadi

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引用次数: 0

Abstract

Introduction: Hirschsprung disease (HSCR) is a disorder caused by the failure of neural crest migration leading to an aganglionic colon and functional obstruction. Transabdominal Yancey-Soave pull-through is one of the definitive therapies for this condition. Prognostic factors, including sex, aganglionosis type, age at definitive surgery, nutritional status, eosinophilia and lymphocytosis, might influence the outcomes of the pull-through. We evaluated the functional outcomes of HSCR patients after Yancey- Soave surgery and associated them with the prognostic factors.

Materials and methods: The study included Hirschsprung patients aged ≥3 and <18 years who underwent Yancey- Soave surgery at our hospital. The functional outcomes were evaluated using the Krickenbeck classification to determine voluntary bowel movement (VBM), constipation and soiling.

Results: Most (82.6%) patients showed VBM, 26.1% had constipation and 4.3% suffered from soiling. Among 23 patients who received Yancey-Soave surgery, 8 (34.8%) had eosinophilia and 5 (21.7%) had lymphocytosis. However, no significant differences were observed between eosinophilia and non-eosinophilia groups for VBM (p=1.0), constipation (p= 0.621) or soiling (p=0.738). Similarly, no significant differences were found between lymphocytosis and nonlymphocytosis groups for VBM (p=1.0), constipation (p=0.545) or soiling (p=0.973). Moreover, no other prognostic factors affected the functional outcomes after Yancey- Soave surgery (p>0.05).

Conclusion: Our study shows that eosinophilia and lymphocytosis might not affect the functional outcome of patients with HSCR following Yancey-Soave surgery. In addition, sex, aganglionosis type, age at definitive surgery and nutritional status might not influence the functional outcome after definitive surgery. Further, a more extensive study is essential to clarify our findings.

本刊更多论文

嗜酸性粒细胞增多症和淋巴细胞增多症与经腹Yancey-Soave牵拉术后赫氏prung病患者功能预后的关系。

简介赫氏病（HSCR）是一种因神经嵴迁移失败而导致无结肠和功能性梗阻的疾病。经腹 Yancey-Soave 拉通术是治疗这种疾病的有效疗法之一。预后因素，包括性别、无结肠类型、明确手术时的年龄、营养状况、嗜酸性粒细胞增多症和淋巴细胞增多症，可能会影响拉通术的结果。我们评估了 Yancey- Soave 手术后 HSCR 患者的功能预后，并将其与预后因素联系起来：研究对象包括年龄≥3 岁的赫氏贲门失弛缓症患者：大多数患者（82.6%）表现为VBM，26.1%有便秘，4.3%有便意。在接受 Yancey-Soave 手术的 23 名患者中，8 人（34.8%）有嗜酸性粒细胞增多症，5 人（21.7%）有淋巴细胞增多症。然而，嗜酸性粒细胞增多组和非嗜酸性粒细胞增多组在 VBM（p=1.0）、便秘（p= 0.621）或便溺（p=0.738）方面没有明显差异。同样，淋巴细胞增多组和非淋巴细胞增多组在 VBM（p=1.0）、便秘（p=0.545）或便溺（p=0.973）方面也无明显差异。此外，没有其他预后因素会影响 Yancey- Soave 手术后的功能预后（p>0.05）：我们的研究表明，嗜酸性粒细胞增多症和淋巴细胞增多症可能不会影响接受 Yancey-Soave 手术的 HSCR 患者的功能预后。结论：我们的研究表明，嗜酸性粒细胞增多症和淋巴细胞增多症可能不会影响接受 Yancey-Soave 手术的 HSCR 患者的功能预后。此外，为了澄清我们的研究结果，有必要进行更广泛的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medical Journal of Malaysia Medicine-Medicine (all)

CiteScore

1.20

自引率

0.00%

发文量

165

期刊介绍： Published since 1890 this journal originated as the Journal of the Straits Medical Association. With the formation of the Malaysian Medical Association (MMA), the Journal became the official organ, supervised by an editorial board. Some of the early Hon. Editors were Mr. H.M. McGladdery (1960 - 1964), Dr. A.A. Sandosham (1965 - 1977), Prof. Paul C.Y. Chen (1977 - 1987). It is a scientific journal, published quarterly and can be found in medical libraries in many parts of the world. The Journal also enjoys the status of being listed in the Index Medicus, the internationally accepted reference index of medical journals. The editorial columns often reflect the Association''s views and attitudes towards medical problems in the country. The MJM aims to be a peer reviewed scientific journal of the highest quality. We want to ensure that whatever data is published is true and any opinion expressed important to medical science. We believe being Malaysian is our unique niche; our priority will be for scientific knowledge about diseases found in Malaysia and for the practice of medicine in Malaysia. The MJM will archive knowledge about the changing pattern of human diseases and our endeavours to overcome them. It will also document how medicine develops as a profession in the nation. We will communicate and co-operate with other scientific journals in Malaysia. We seek articles that are of educational value to doctors. We will consider all unsolicited articles submitted to the journal and will commission distinguished Malaysians to write relevant review articles. We want to help doctors make better decisions and be good at judging the value of scientific data. We want to help doctors write better, to be articulate and precise.