Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model.

IF 2.5 Q2 GASTROENTEROLOGY & HEPATOLOGY
Yuan-Yuan Chen, Li Yang, Jun Li, Sheng-Xiang Rao, Ying Ding, Meng-Su Zeng
{"title":"Gadoxetic acid-enhanced magnetic resonance imaging in the assessment of hepatic sinusoidal obstruction syndrome in a mouse model.","authors":"Yuan-Yuan Chen, Li Yang, Jun Li, Sheng-Xiang Rao, Ying Ding, Meng-Su Zeng","doi":"10.4254/wjh.v16.i8.1167","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Neoadjuvant chemotherapy can cause hepatic sinusoidal obstruction syndrome (SOS) in patients with colorectal cancer liver metastases and increases postoperative morbidity and mortality.</p><p><strong>Aim: </strong>To evaluate T<sub>1</sub> mapping based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for diagnosis of hepatic SOS induced by monocrotaline.</p><p><strong>Methods: </strong>Twenty-four mice were divided into control (<i>n</i> = 10) and experimental (<i>n</i> = 14) groups. The experimental groups were injected with monocrotaline 2 or 6 days before MRI. MRI parameters were: T1 relaxation time before enhancement; T1 relaxation time 20 minutes after enhancement (T<sub>1post</sub>); a reduction in T1 relaxation time (△T<sub>1</sub>%); and first enhancement slope percentage of the liver parenchyma (ESP). Albumin and bilirubin score was determined. Histological results served as a reference. Liver parenchyma samples from the control and experimental groups were analyzed by western blotting, and organic anion transporter polypeptide 1 (OATP1) was measured.</p><p><strong>Results: </strong>T<sub>1post</sub>, △T<sub>1</sub>%, and ESP of the liver parenchyma were significantly different between two groups (all <i>P</i> < 0.001) and significantly correlated with the total histological score of hepatic SOS (<i>r</i> = -0.70, 0.68 and 0.79; <i>P</i> < 0.001). △T<sub>1</sub>% and ESP were positively correlated with OATP1 levels (<i>r</i> = 0.82, 0.85; <i>P</i> < 0.001), whereas T<sub>1post</sub> had a negative correlation with OATP1 levels (<i>r</i> = -0.83; <i>P</i> < 0.001).</p><p><strong>Conclusion: </strong>T<sub>1</sub> mapping based on gadoxetic acid-enhanced MRI may be useful for diagnosis of hepatic SOS, and MRI parameters were associated with OATP1 levels.</p>","PeriodicalId":23687,"journal":{"name":"World Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":2.5000,"publicationDate":"2024-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362905/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"World Journal of Hepatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4254/wjh.v16.i8.1167","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
引用次数: 0

Abstract

Background: Neoadjuvant chemotherapy can cause hepatic sinusoidal obstruction syndrome (SOS) in patients with colorectal cancer liver metastases and increases postoperative morbidity and mortality.

Aim: To evaluate T1 mapping based on gadoxetic acid-enhanced magnetic resonance imaging (MRI) for diagnosis of hepatic SOS induced by monocrotaline.

Methods: Twenty-four mice were divided into control (n = 10) and experimental (n = 14) groups. The experimental groups were injected with monocrotaline 2 or 6 days before MRI. MRI parameters were: T1 relaxation time before enhancement; T1 relaxation time 20 minutes after enhancement (T1post); a reduction in T1 relaxation time (△T1%); and first enhancement slope percentage of the liver parenchyma (ESP). Albumin and bilirubin score was determined. Histological results served as a reference. Liver parenchyma samples from the control and experimental groups were analyzed by western blotting, and organic anion transporter polypeptide 1 (OATP1) was measured.

Results: T1post, △T1%, and ESP of the liver parenchyma were significantly different between two groups (all P < 0.001) and significantly correlated with the total histological score of hepatic SOS (r = -0.70, 0.68 and 0.79; P < 0.001). △T1% and ESP were positively correlated with OATP1 levels (r = 0.82, 0.85; P < 0.001), whereas T1post had a negative correlation with OATP1 levels (r = -0.83; P < 0.001).

Conclusion: T1 mapping based on gadoxetic acid-enhanced MRI may be useful for diagnosis of hepatic SOS, and MRI parameters were associated with OATP1 levels.

钆醋酸增强磁共振成像在小鼠肝窦阻塞综合征模型中的评估。
背景:目的:评估基于钆醋酸增强磁共振成像(MRI)的T1图谱对单克隆诱导的肝脏SOS的诊断:24只小鼠分为对照组(n = 10)和实验组(n = 14)。实验组在核磁共振成像前 2 天或 6 天注射单克洛汀。核磁共振成像参数为增强前的 T1 松弛时间;增强后 20 分钟的 T1 松弛时间(T1post);T1 松弛时间的减少(△T1%);肝实质的首次增强斜率百分比(ESP)。测定白蛋白和胆红素评分。组织学结果作为参考。对对照组和实验组的肝实质样本进行了 Western 印迹分析,并测定了有机阴离子转运体多肽 1(OATP1):结果:两组肝实质的T1post、△T1%和ESP有显著差异(均P < 0.001),并与肝脏SOS组织学总分显著相关(r = -0.70、0.68和0.79;P < 0.001)。△T1%和ESP与OATP1水平呈正相关(r = 0.82, 0.85; P < 0.001),而T1post与OATP1水平呈负相关(r = -0.83; P < 0.001):结论:基于钆醋酸增强磁共振成像的T1图谱可用于诊断肝脏SOS,磁共振成像参数与OATP1水平相关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
World Journal of Hepatology
World Journal of Hepatology GASTROENTEROLOGY & HEPATOLOGY-
CiteScore
4.10
自引率
4.20%
发文量
172
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信