Evaluation of different scoring systems for repeating Transarterial Chemoembolization in Egyptian patients with Hepatocellular Carcinoma.

IF 1.6 Q2 MEDICINE, GENERAL & INTERNAL
Omkolsoum Alhaddad, Asmaa Gomaa, Merhan El Shamandy, Mohamed Kohla, Ahmed Edrees, Reham Ashour
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引用次数: 0

Abstract

Background: Hepatocellular carcinoma (HCC) patients undergoing transarterial chemoembolization (TACE) have a diverse range of outcomes due to their high degree of heterogeneity. Therefore, different predictive scoring systems have been created to assist in decision-making regarding retreatment with TACE. We compared the predictive capabilities of different scoring systems, such as ART, ABCR, and SNACOR, for prediction of the outcome of subsequent TACE in HCC patients.

Method: In this retrospective study, the three scoring systems were compared for their capability of predicting the outcome of repeating TACE in 149 HCC patients treated at the National Liver Institute, Egypt, between January 2017 and December 2019. We used the likelihood ratio to select the model with the highest predictive capability for overall survival (OS).

Results: According to our data, the amount of tumor, the change in Barcelona Clinic Liver Cancer (BCLC) stage following TACE, and the SNACOR score (with a 95% confidence range for HR 1.0305-1.256 and p-value = 0.0106) were the most predictive variables. It was also shown that the ABCR score was a good predictor of survival (90 patients had an ABCR score ≤ 0 with a P- value <0.0001, 56 patients had 0 < ABCR < 4 with a P-value <0.0001, and the ART score was not useful in predicting OS (P-value = 0.18).

Conclusion: The SNACOR score is the most predictive score for OS and would be the most helpful scoring system in decision-making regarding retreatment with TACE.

对埃及肝细胞癌患者重复经动脉化疗栓塞术的不同评分系统进行评估。
背景:接受经动脉化疗栓塞术(TACE)治疗的肝细胞癌(HCC)患者因其高度异质性而有不同的治疗结果。因此,人们建立了不同的预测评分系统,以协助TACE再治疗的决策。我们比较了 ART、ABCR 和 SNACOR 等不同评分系统对 HCC 患者后续 TACE 治疗结果的预测能力:在这项回顾性研究中,我们对 2017 年 1 月至 2019 年 12 月期间在埃及国家肝脏研究所接受治疗的 149 例 HCC 患者中,三种评分系统预测重复 TACE 结果的能力进行了比较。我们使用似然比来选择对总生存期(OS)预测能力最强的模型:根据我们的数据,肿瘤数量、TACE后巴塞罗那临床肝癌(BCLC)分期的变化以及SNACOR评分(HR的95%置信区间为1.0305-1.256,P值=0.0106)是预测能力最强的变量。研究还表明,ABCR 评分是预测生存率的良好指标(90 名患者的 ABCR 评分≤0,P 值为 结论:ABCR 评分是预测生存率的重要指标:SNACOR 评分是最能预测患者生存率的评分,也是对 TACE 再治疗决策最有帮助的评分系统。
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来源期刊
Romanian Journal of Internal Medicine
Romanian Journal of Internal Medicine MEDICINE, GENERAL & INTERNAL-
CiteScore
3.20
自引率
5.30%
发文量
35
审稿时长
15 weeks
期刊介绍: Romanian Journal of Physics is a journal publishing physics contributions on the following themes: •Theoretical Physics & Applied Mathematics •Nuclear Physics •Solid State Physics & Materials Science •Statistical Physics & Quantum Mechanics •Optics •Spectroscopy •Plasma & Lasers •Nuclear & Elementary Particles Physics •Atomic and Molecular Physics •Astrophysics •Atmosphere and Earth Science •Environment Protection
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