Exploring the relationship between genetic instability and health outcomes in acute and chronic post-COVID syndrome.

IF 2.5 4区 医学 Q3 GENETICS & HEREDITY
Mutagenesis Pub Date : 2024-11-02 DOI:10.1093/mutage/geae022
Bruna Alves Alonso Martins, Ana Leticia Hilario Garcia, Malu Siqueira Borges, Juliana Picinini, Enaile Tuliczewski Serpa, Daiane Dias Ribeiro Nobles, Luana Letícia Silva, Daiana Dalberto, Alana Witt Hansen, Fernando Rosado Spilki, Lavínia Schuler-Faccini, Pabulo Henrique Rampelotto, Juliana Da Silva
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Abstract

The COVID-19 pandemic has led to the emergence of acute and chronic post-COVID syndromes, which present diverse clinical manifestations. The underlying pathophysiology of these conditions is not yet fully understood, but genetic instability has been proposed as a potential contributing factor. This study aimed to explore the differential impact of physical and psychological health factors on genetic instability in individuals with acute and chronic post-COVID syndromes. In this study, three groups of subjects were analyzed: a control group, an acute post-COVID group, and a chronic post-COVID group, with a total of 231 participants. The participants were assessed using a questionnaire for long-COVID-19COVID, and female participants reported more symptoms than male participants in areas related to fatigue, memory, mental health, and well-being during the chronic phase. Genetic instability was assessed using the comet assay, and participants' physical and psychological profiles were evaluated. The overall results showed no significant differences in DNA damage, as measured by the comet assay, among the three groups, suggesting that genetic instability, as assessed by this method, may not be a primary driver of the distinct clinical presentations observed in post-COVID syndromes. However, when gender was considered, male participants in the acute long COVID group exhibited higher levels of genetic instability compared to females. Multiple linear regression analysis revealed that gender, age, and waist circumference were significant predictors of DNA damage. Among females in the acute group, sexual health, and eye-related symptoms significantly influenced the increase in DNA damage. These findings indicate the need for further investigation on the gender-specific differences in genetic instability and their potential implications for the pathophysiology of post-COVID syndromes. Exploring alternative markers of genetic instability and the interplay between genetic, inflammatory, and cellular processes could provide valuable insights for the management of these debilitating post-viral sequelae.

探索遗传不稳定性与急性和慢性后 COVID 综合征健康结果之间的关系。
COVID-19 大流行导致出现了急性和慢性后 COVID 综合征,其临床表现多种多样。这些病症的潜在病理生理学尚不完全清楚,但遗传不稳定性已被认为是潜在的诱因之一。本研究旨在探讨生理和心理健康因素对急性和慢性后 COVID 综合征患者遗传不稳定性的不同影响。本研究分析了三组受试者:对照组、急性后 COVID 组和慢性后 COVID 组,共计 231 人。研究人员使用长COVID-19COVID调查问卷对受试者进行了评估,在慢性期,女性受试者比男性受试者报告了更多与疲劳、记忆力、心理健康和幸福感相关的症状。使用彗星测定法对遗传不稳定性进行了评估,并对参与者的身体和心理状况进行了评估。总体结果表明,用彗星测定法测量的 DNA 损伤在三个组别之间没有明显差异,这表明用这种方法评估的遗传不稳定性可能不是导致后 COVID 综合征出现不同临床表现的主要原因。然而,如果考虑到性别因素,急性长COVID组中男性参与者的遗传不稳定性水平高于女性。多元线性回归分析显示,性别、年龄和腰围是 DNA 损伤的重要预测因素。在急性组的女性中,性健康和眼部相关症状对DNA损伤的增加有明显影响。这些发现表明,有必要进一步研究遗传不稳定性的性别差异及其对COVID后综合征病理生理学的潜在影响。探索遗传不稳定性的替代标志物以及遗传、炎症和细胞过程之间的相互作用可为治疗这些使人衰弱的病毒后遗症提供有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Mutagenesis
Mutagenesis 生物-毒理学
CiteScore
5.90
自引率
3.70%
发文量
22
审稿时长
6-12 weeks
期刊介绍: Mutagenesis is an international multi-disciplinary journal designed to bring together research aimed at the identification, characterization and elucidation of the mechanisms of action of physical, chemical and biological agents capable of producing genetic change in living organisms and the study of the consequences of such changes.
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