Translating the theranostic concept to neuro-oncology: disrupting barriers.

IF 41.6 1区 医学 Q1 ONCOLOGY
Nathalie L Albert, Emilie Le Rhun, Giuseppe Minniti, Maximilian J Mair, Norbert Galldiks, Nelleke Tolboom, Asgeir S Jakola, Maximilian Niyazi, Marion Smits, Antoine Verger, Francesco Cicone, Michael Weller, Matthias Preusser
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引用次数: 0

Abstract

Theranostics integrate molecular imaging and targeted radionuclide therapy for personalised cancer therapy. Theranostic treatments have shown meaningful efficacy in randomised clinical trials and are approved for clinical use in prostate cancer and neuroendocrine tumours. Brain tumours represent an unmet clinical need and theranostics might offer effective treatment options, although specific issues need to be considered for clinical development. In this Policy Review, we discuss opportunities and challenges of developing targeted radionuclide therapies for the treatment of brain tumours including glioma, meningioma, and brain metastasis. The rational choice of molecular treatment targets is highlighted, including the potential relevance of different types of targeted radionuclide therapeutics, and the role of the blood-brain barrier and blood-tumour barrier. Furthermore, we discuss considerations for effective clinical trial design and conduct, as well as logistical and regulatory challenges for implementation of radionuclide therapies into neuro-oncological practice. Rational development will foster successful translation of the theranostic concept to brain tumours.

将治疗概念转化为神经肿瘤学:打破障碍。
Theranostics 将分子成像和放射性核素靶向治疗整合在一起,用于个性化癌症治疗。治疗放射治疗在随机临床试验中已显示出显著疗效,并已获准用于前列腺癌和神经内分泌肿瘤的临床治疗。脑肿瘤是一项尚未满足的临床需求,治疗学可能提供有效的治疗方案,但临床开发需要考虑具体问题。在本政策综述中,我们将讨论开发放射性核素靶向疗法治疗脑肿瘤(包括胶质瘤、脑膜瘤和脑转移瘤)的机遇与挑战。我们强调了分子治疗靶点的合理选择,包括不同类型靶向放射性核素疗法的潜在相关性,以及血脑屏障和血瘤屏障的作用。此外,我们还讨论了有效设计和开展临床试验的注意事项,以及将放射性核素疗法应用于神经肿瘤实践所面临的后勤和监管挑战。合理的开发将促进治疗概念在脑肿瘤领域的成功转化。
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来源期刊
Lancet Oncology
Lancet Oncology 医学-肿瘤学
CiteScore
62.10
自引率
1.00%
发文量
913
审稿时长
3-8 weeks
期刊介绍: The Lancet Oncology is a trusted international journal that addresses various topics in clinical practice, health policy, and global oncology. It covers a wide range of cancer types, including breast, endocrine system, gastrointestinal, genitourinary, gynaecological, haematological, head and neck, neurooncology, paediatric, thoracic, sarcoma, and skin cancers. Additionally, it includes articles on epidemiology, cancer prevention and control, supportive care, imaging, and health-care systems. The journal has an Impact Factor of 51.1, making it the leading clinical oncology research journal worldwide. It publishes different types of articles, such as Articles, Reviews, Policy Reviews, Personal Views, Clinical Pictures, Comments, Correspondence, News, and Perspectives. The Lancet Oncology also collaborates with societies, governments, NGOs, and academic centers to publish Series and Commissions that aim to drive positive changes in clinical practice and health policy in areas of global oncology that require attention.
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