Association Between Clubfoot and Neonatal Abstinence Syndrome in the United States, 2018-2022.

IF 1.4 3区 医学 Q3 ORTHOPEDICS
Meera M Dhodapkar, Anshu Jonnalagadda, Adrienne R Socci, Corinna Franklin
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引用次数: 0

Abstract

Purpose: The United States has seen an increase in opioid use and misuse over the last 2 decades. Infants have been impacted by the opioid epidemic, with a reported 5-fold increase in the incidence of neonatal abstinence syndrome (NAS) over the last 2 decades. There are many conditions associated with NAS, and thus, the current study sought to examine the association between NAS and clubfoot.

Methods: The study was retrospective, utilizing patient data from the Pediatric Hospital Information System (PHIS) database. Neonates presenting to any PHIS hospital between 2018 and 2022 were identified and included in the study. Patients with NAS and clubfoot were identified utilizing the International Classification of Diseases (ICD)-9 and 10 codes. Univariable and multivariable analyses were performed to investigate associations between clubfoot, race, ethnicity, insurance type, gestational age, length of stay, NAS, and comorbidity burden.

Results: A total of 458,274 patients were identified, of whom 2337 (0.5%) had a clubfoot diagnosis and 5431 (1.2%) had a diagnosis of NAS. Multivariable logistic regression revealed higher independent odds of clubfoot among patients with a diagnosis of NAS [odds ratio (OR): 1.49], patients with a greater number of comorbidities (OR: 4.75 for 1 comorbidity vs. none, and 21.19 for 2+ comorbidities, vs. none), patients with a greater gestational age (OR: 1.01 per week increase), and those with an increased length of stay (OR: 1.00 per day increase). A lower independent odds of clubfoot was observed among patients of Asian race (OR: 0.66), Hispanic/Latino ethnicity (OR: 0.80), non-Hispanic Black (OR: 0.75), and multiracial (OR: 0.80) ethnicity/race relative to non-Hispanic/Latino White patients (P<0.05 for all).

Conclusion: Patients with a diagnosis of NAS demonstrated higher odds of clubfoot, in addition to sociodemographic factors, as well as comorbidity burden.

2018-2022 年美国马蹄内翻足与新生儿戒断综合征之间的关系。
目的:在过去 20 年中,美国阿片类药物的使用和滥用有所增加。婴儿也受到了阿片类药物流行的影响,据报道,在过去 20 年中,新生儿禁欲综合征(NAS)的发病率增加了 5 倍。与NAS相关的疾病有很多,因此,本研究试图探讨NAS与足癣之间的关系:本研究是一项回顾性研究,利用的是儿科医院信息系统(PHIS)数据库中的患者数据。2018年至2022年期间在任何一家PHIS医院就诊的新生儿均被确定并纳入研究。利用国际疾病分类(ICD)-9和10代码确定NAS和马蹄内翻足患者。研究人员进行了单变量和多变量分析,以调查足癣、种族、民族、保险类型、妊娠年龄、住院时间、NAS和合并症负担之间的关联:共发现 458 274 名患者,其中 2337 人(0.5%)确诊为马蹄内翻足,5431 人(1.2%)确诊为 NAS。多变量逻辑回归显示,诊断为NAS的患者[几率比(OR):1.49]、合并症较多的患者(1种合并症与无合并症相比,OR:4.75;2种以上合并症与无合并症相比,OR:21.19)、胎龄较大的患者(OR:每增加一周增加1.01)和住院时间较长的患者(OR:每增加一天增加1.00)发生马蹄内翻足的独立几率较高。与非西班牙裔/拉美裔白人患者相比,亚洲人种(OR:0.66)、西班牙裔/拉美裔人种(OR:0.80)、非西班牙裔黑人(OR:0.75)和多种族(OR:0.80)人种/人种的患者发生足外翻的几率较低(PConclusion:除社会人口因素和合并症负担外,诊断为NAS的患者患足癣的几率更高。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.30
自引率
17.60%
发文量
512
审稿时长
6 months
期刊介绍: ​Journal of Pediatric Orthopaedics is a leading journal that focuses specifically on traumatic injuries to give you hands-on on coverage of a fast-growing field. You''ll get articles that cover everything from the nature of injury to the effects of new drug therapies; everything from recommendations for more effective surgical approaches to the latest laboratory findings.
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