Recent Advances in Development of Biosensors for Monitoring of Airborne Microorganisms.

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Zahra Mousavian, Ensieh Fahimi-Kashani, Vahidreza Nafisi, Nafiseh Fahimi-Kashani
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引用次数: 0

Abstract

Background: The early detection of infectious microorganisms is crucial for preventing and controlling the transmission of diseases. This article provides a comprehensive review of biosensors based on various diagnostic methods for measuring airborne pathogens.

Objective: This article aims to explore recent advancements in the field of biosensors tailored for the detection and monitoring of airborne microorganisms, offering insights into emerging technologies and their potential applications in environmental surveillance and public health management.

Materials and methods: The study summarizes the research conducted on novel methods of detecting airborne microorganisms using different biological sensors, as well as the application of signal amplification technologies such as polymerase chain reaction (PCR), immunoassay reactions, molecular imprinted polymers (MIP) technique, lectin and cascade reactions, and nanomaterials.

Results: Antibody and PCR detection methods are effective for specific microbial strains, but they have limitations including limited stability, high cost, and the need for skilled operators with basic knowledge of the target structure. Biosensors based on MIP and lectin offer a low-cost, stable, sensitive, and selective alternative to antibodies and PCR. However, challenges remain, such as the detection of small gas molecules by MIP and the lower sensitivity of lectins compared to antibodies. Additionally, achieving high sensitivity in complex environments poses difficulties for both methods.

Conclusion: The development of sensitive, reliable, accessible, portable, and inexpensive biosensors holds great potential for clinical and environmental applications, including disease diagnosis, treatment monitoring, and point-of-care testing, offering a promising future in this field. This review presents an overview of biosensor detection principles, covering component identification, energy conversion principles, and signal amplification. Additionally, it summarizes the research and applications of biosensors in the detection of airborne microorganisms. The latest advancements and future trends in biosensor detection of airborne microorganisms are also analyzed.

用于监测空气中微生物的生物传感器的最新进展。
背景:早期检测传染性微生物对于预防和控制疾病传播至关重要。本文全面综述了基于各种诊断方法的生物传感器,用于测量空气中的病原体:本文旨在探讨专门用于检测和监测空气传播微生物的生物传感器领域的最新进展,深入探讨新兴技术及其在环境监测和公共卫生管理中的潜在应用:研究总结了利用不同生物传感器检测空气传播微生物的新型方法,以及聚合酶链式反应(PCR)、免疫测定反应、分子印迹聚合物(MIP)技术、凝集素和级联反应以及纳米材料等信号放大技术的应用:结果:抗体和 PCR 检测方法对特定的微生物菌株很有效,但它们也有局限性,包括稳定性有限、成本高,以及需要具备目标结构基础知识的熟练操作人员。基于 MIP 和凝集素的生物传感器提供了一种替代抗体和 PCR 的低成本、稳定、灵敏和选择性的方法。然而,挑战依然存在,例如 MIP 对小气体分子的检测,以及凝集素与抗体相比灵敏度较低等。此外,在复杂环境中实现高灵敏度也给这两种方法带来了困难:开发灵敏、可靠、易用、便携和廉价的生物传感器在临床和环境应用方面具有巨大潜力,包括疾病诊断、治疗监测和护理点检测,为这一领域带来了广阔的前景。本综述概述了生物传感器的检测原理,包括元件识别、能量转换原理和信号放大。此外,它还总结了生物传感器在空气微生物检测方面的研究和应用。文章还分析了生物传感器检测空气中微生物的最新进展和未来趋势。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Iranian Journal of Biotechnology
Iranian Journal of Biotechnology BIOTECHNOLOGY & APPLIED MICROBIOLOGY-
CiteScore
2.60
自引率
7.70%
发文量
20
期刊介绍: Iranian Journal of Biotechnology (IJB) is published quarterly by the National Institute of Genetic Engineering and Biotechnology. IJB publishes original scientific research papers in the broad area of Biotechnology such as, Agriculture, Animal and Marine Sciences, Basic Sciences, Bioinformatics, Biosafety and Bioethics, Environment, Industry and Mining and Medical Sciences.
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