Neuraxial labor analgesia in a parturient with carnitine palmitoyl transferase type II deficiency: a case report

IF 2.6 3区医学 Q2 ANESTHESIOLOGY

International journal of obstetric anesthesia Pub Date : 2024-08-08 DOI:10.1016/j.ijoa.2024.104246

T.K. Bowman, A. Oweidat, N. El Hage Chehade, M. Cheriyan, S. Ayad, M. Hoyt

引用次数: 0

Abstract

Carnitine Palmitoyl Transferase Type II (CPT II) deficiency is a disorder of fatty acid beta oxidation that causes decreased adenosine triphosphate (ATP) and ketone production during periods of fasting or high energy requirements. Labor and delivery can precipitate attacks for parturients with this disorder, causing hypoglycemia, muscle weakness, rhabdomyolysis, and kidney failure. Anesthetic management considers the delivery mode and anesthetic medications available to reduce these risks. We present the case of a pregnant patient with CPT II deficiency with labor epidural analgesia and a vaginal delivery, with alternative plans had a different delivery mode been required.

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肉碱棕榈酰转移酶 II 型缺乏症产妇的神经镇痛：病例报告。

肉碱棕榈酰转移酶 II 型（CPT II）缺乏症是一种脂肪酸 beta 氧化障碍，会导致在禁食或高能量需求期间三磷酸腺苷（ATP）和酮体生成减少。患有这种疾病的产妇在分娩时会突然发病，导致低血糖、肌肉无力、横纹肌溶解和肾衰竭。麻醉管理应考虑分娩方式和可用的麻醉药物，以降低这些风险。我们介绍了一名患有 CPT II 缺乏症的孕妇的病例，她在分娩时接受了硬膜外镇痛并经阴道分娩，如果需要采用不同的分娩方式，她还可以选择其他方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International journal of obstetric anesthesia 医学-妇产科学

CiteScore

4.70

自引率

7.10%

发文量

285

审稿时长

58 days

期刊介绍： The International Journal of Obstetric Anesthesia is the only journal publishing original articles devoted exclusively to obstetric anesthesia and bringing together all three of its principal components; anesthesia care for operative delivery and the perioperative period, pain relief in labour and care of the critically ill obstetric patient. • Original research (both clinical and laboratory), short reports and case reports will be considered. • The journal also publishes invited review articles and debates on topical and controversial subjects in the area of obstetric anesthesia. • Articles on related topics such as perinatal physiology and pharmacology and all subjects of importance to obstetric anaesthetists/anesthesiologists are also welcome. The journal is peer-reviewed by international experts. Scholarship is stressed to include the focus on discovery, application of knowledge across fields, and informing the medical community. Through the peer-review process, we hope to attest to the quality of scholarships and guide the Journal to extend and transform knowledge in this important and expanding area.