Effects of Isoflavone Interventions on Bone Metabolism in Perimenopausal and Postmenopausal Women: An Umbrella Review of Meta-Analyses of Randomized Controlled Trials

IF 3.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Endocrine Practice Pub Date : 2025-02-01 DOI:10.1016/j.eprac.2024.08.009

Lifang Zhuge MM , Lanlan Chen MBBS , Weiping Pan MBBS

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引用次数: 0

Abstract

Objective

Previous meta-analyses have investigated the effects of isoflavones on bone metabolism in perimenopausal or postmenopausal women. However, there were still conflicting results. Thereby, this umbrella review assessed the existing meta-analysis evidence of the effects of isoflavone interventions on bone metabolism in perimenopausal and postmenopausal women.

Methods

This study was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses. From the inception until August 24, 2023, PubMed, Embase, Cochrane, and Web of Science databases were searched to identify meta-analyses of randomized controlled trials. The outcomes included bone mineral densities (BMDs), and bone turnover markers of osteocalcin, bone-specific alkaline phosphatase, pyridinoline, deoxypyridinoline, Procollagen Type 1 N-Terminal Propeptide, and C-telopeptide of Type 1 Collagen. The random-effects model was used to recalculate the extracted effect sizes. Mean difference (MD) was used as a summary effect measure.

Results

Ten meta-analyses of randomized controlled trials were included. The isoflavone intervention was associated with increased BMDs in lumbar spine (MD: 11.50 mg/cm², 95% confidence interval (CI): 6.46 to 16.55), femoral neck (MD: 2.03%, 95% CI: 0.57 to 3.50), and top hip (MD: 0.31%, 95% CI: 0.03 to 0.59) in perimenopausal and postmenopausal women.

Conclusion

Our findings indicate that isoflavone interventions have the potential to improve BMD at different bone sites, including the lumbar spine, femoral neck, and total hip in perimenopausal and postmenopausal women. Isoflavone may be considered a complementary option in the bone loss of perimenopausal and postmenopausal women.

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异黄酮干预对围绝经期和绝经后妇女骨代谢的影响：随机对照试验荟萃分析综述。

研究目的以往的荟萃分析研究了异黄酮对围绝经期或绝经后妇女骨代谢的影响。然而，结果仍然相互矛盾。因此，本综述评估了异黄酮干预对围绝经期和绝经后妇女骨代谢影响的现有荟萃分析证据：本研究遵循系统综述和荟萃分析首选报告项目（PRISMA）指南进行。从开始到 2023 年 8 月 24 日，对 PubMed、Embase、Cochrane 和 Web of Science 数据库进行了检索，以确定随机对照试验 (RCT) 的荟萃分析。研究结果包括骨矿物质密度（BMDs）、骨钙素（OC）、骨特异性碱性磷酸酶（BAP）、吡啶啉（PYD）、脱氧吡啶啉（DPD）、1型胶原蛋白N端前肽（P1NP）和1型胶原蛋白C-十肽（CTX）等骨转换标志物（BTMs）。随机效应模型用于重新计算提取的效应大小。采用平均差（MD）作为效应的总结指标：结果：共纳入了 10 项 RCT 的荟萃分析。在围绝经期和绝经后妇女中，异黄酮干预与腰椎（MD：11.50 mg/cm2，95% 置信区间（CI）：6.46 至 16.55）、股骨颈（MD：2.03%，95% CI：0.57 至 3.50）和髋上部（MD：0.31%，95% CI：0.03 至 0.59）BMD 的增加有关：我们的研究结果表明，异黄酮干预措施有可能改善围绝经期和绝经后妇女不同骨骼部位的 BMD，包括腰椎、股骨颈和全髋。异黄酮可被视为围绝经期和绝经后妇女骨质流失的一种补充选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Practice ENDOCRINOLOGY & METABOLISM-

CiteScore

7.60

自引率

2.40%

发文量

546

审稿时长

41 days

期刊介绍： Endocrine Practice (ISSN: 1530-891X), a peer-reviewed journal published twelve times a year, is the official journal of the American Association of Clinical Endocrinologists (AACE). The primary mission of Endocrine Practice is to enhance the health care of patients with endocrine diseases through continuing education of practicing endocrinologists.