Benzothieno[c]quinoline based a novel fluorescent “turn-on” chemosensor for the detection of Fe (III) from aqueous solution

IF 2.7 3区化学 Q2 CHEMISTRY, INORGANIC & NUCLEAR

Inorganica Chimica Acta Pub Date : 2024-08-23 DOI:10.1016/j.ica.2024.122342

Prashant Patil , Ratnamala Sonawane , Su Jeong Park , Satish Balasaheb Nimse , Anil Kuwar

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Abstract

A 6-(thiophen-2-yl)benzo[4,5]thieno[3,2-c]quinoline (QTP), with thiophene and quinoline based moieties as binding sites, has been synthesized and characterized with spectroscopic methods, and DFT. The synthesized probe QTP showed highly sensitive and highly specific fluorescent ‘turn-on’ effect (λem = 280 nm) for the 1:1 binding with Fe³⁺ ions to form probe QTP.Fe³⁺ complex in semi-aqueous medium (acetonitrile:water (50:50; v/v)) and live cells. The 1:1 binding stoichiometry of probe QTP and Fe³⁺ ions were proposed by DFT calculations and confirmed by the NMR spectroscopy, and mass spectrum of probe QTP.Fe³⁺ complex. Importantly, with the LOD 6.37 µM for the detection of Fe³⁺ ions, receptor QTP did not show any interference from potentially competing ions, indicates its biocompatibility. The micromolar limit of detection (6.37 µM), cell permeability, and low cytotoxicity allows the probe QTP to be an outstanding tool for the live-cell imaging and detection of ferric ions in live cells.

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基于苯并噻吩并[c]喹啉的新型荧光 "开启 "化学传感器，用于检测水溶液中的铁（III）含量

我们合成了一种以噻吩和喹啉为结合位点的 6-(噻吩-2-基)苯并[4,5]噻吩并[3,2-c]喹啉（QTP），并利用光谱方法和 DFT 对其进行了表征。合成的探针 QTP 在半水介质（乙腈：水（50:50；v/v））和活细胞中与 Fe3+ 离子以 1:1 的比例结合形成探针 QTP.Fe3+ 复合物，显示出高灵敏度和高特异性的荧光 "开启 "效应（λem = 280 nm）。通过 DFT 计算提出了探针 QTP 与 Fe3+ 离子的 1:1 结合配比，并通过核磁共振光谱和探针 QTP.Fe3+ 复合物的质谱进行了证实。重要的是，Fe3+ 离子的检测限为 6.37 µM，受体 QTP 没有受到任何潜在竞争离子的干扰，这表明它具有生物相容性。微摩尔检测限（6.37 µM）、细胞渗透性和低细胞毒性使探针 QTP 成为活细胞成像和检测活细胞中铁离子的杰出工具。

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来源期刊

Inorganica Chimica Acta 化学-无机化学与核化学

CiteScore

6.00

自引率

3.60%

发文量

440

审稿时长

35 days

期刊介绍： Inorganica Chimica Acta is an established international forum for all aspects of advanced Inorganic Chemistry. Original papers of high scientific level and interest are published in the form of Articles and Reviews. Topics covered include: • chemistry of the main group elements and the d- and f-block metals, including the synthesis, characterization and reactivity of coordination, organometallic, biomimetic, supramolecular coordination compounds, including associated computational studies; • synthesis, physico-chemical properties, applications of molecule-based nano-scaled clusters and nanomaterials designed using the principles of coordination chemistry, as well as coordination polymers (CPs), metal-organic frameworks (MOFs), metal-organic polyhedra (MPOs); • reaction mechanisms and physico-chemical investigations computational studies of metalloenzymes and their models; • applications of inorganic compounds, metallodrugs and molecule-based materials. Papers composed primarily of structural reports will typically not be considered for publication.