Current trends in silica based drug delivery systems

European Journal of Medicinal Chemistry Reports Pub Date : 2024-08-22 DOI:10.1016/j.ejmcr.2024.100206

Rozhan Khoz , Fateme Yazdian , Mehrab Pourmadadi , Abbas Rahdar , Sonia Fathi-karkan , Sadanand Pandey

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Abstract

Traditional drug delivery systems have fallen short in addressing the complex medical and therapeutic needs of patients, necessitating the development of more efficient alternatives. These novel systems aim to enhance treatment efficacy while minimizing adverse effects. Advances in drug delivery technology have significantly improved drug loading and release, administration methods, pharmacological profiles, and the creation of innovative drug formulations. This review delves into current methodologies employed in silica-based targeted drug delivery systems. After examining the structure and properties of various silicas, we focus on mesoporous nanoparticles for targeted drug delivery, exploring existing approaches and addressing critical concerns such as silica safety and biodegradability. Additionally, this review provides a brief overview of bioassays, cell tracking, and tumor-specific targeting strategies.

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硅基给药系统的当前趋势

传统的给药系统无法满足患者复杂的医疗和治疗需求，因此有必要开发更有效的替代品。这些新型系统旨在提高疗效，同时最大限度地减少不良反应。给药技术的进步极大地改善了药物的负载和释放、给药方法、药理学特征以及创新药物制剂的创造。本综述深入探讨了目前在二氧化硅靶向给药系统中采用的方法。在研究了各种二氧化硅的结构和特性后，我们将重点关注用于靶向给药的介孔纳米颗粒，探讨现有的方法并解决二氧化硅的安全性和生物降解性等关键问题。此外，本综述还简要介绍了生物测定、细胞追踪和肿瘤特异性靶向策略。

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来源期刊

European Journal of Medicinal Chemistry Reports

CiteScore

4.50

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0.00%

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