Pincer-metal complexes possessing pyrrolidine: synthesis, structural characterization, and cytotoxicity

IF 2.1 3区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Journal of Organometallic Chemistry Pub Date : 2024-08-26 DOI:10.1016/j.jorganchem.2024.123346

Yu Ye , Shulei Wu , Zaoduan Wu , Qianqian Lei, Xuan Yang, Hongyu Cai, Tao Jiang, Yuxuan Chen, Mingzu Dai, Zehua Yang

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Abstract

Five NNN type pincer-metal complexes NNN-CuCl₂ (6a), (R,R)-NNN-CuCl₂ (6b), NNN-NiCl₂⋅H₂O (6c), (R,R)-NNN-NiCl₂⋅H₂O (6d), and (R,R)-NNN-CoCl₂ (6e) were synthesized in reasonable yield and characterized by HRMS, and/or single crystal X-ray diffractions. The ORTEP drawing of complexes 6b, 6e shows that the coordination geometry around the metal center is approximately square pyramidal. The cytotoxicities of these compounds were evaluated in vitro against K562, 293T, MCF-7, SiHa, and SH-SY5Y cell lines. The pharmacological results showed that most of the prepared compounds displayed good selective cytotoxicity toward K562 cells. Among them, compounds 6a and 6b possessed good anticancer activity against all cancer cells with less cell toxicity on 293T cells, even superior to cisplatin.

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具有吡咯烷的钳形金属络合物：合成、结构特征和细胞毒性

我们合成了五种 NNN 型钳形金属配合物 NNN-CuCl2 (6a)、(R,R)-NNN-CuCl2 (6b)、NNN-NiCl2⋅H2O (6c)、(R,R)-NNN-NiCl2⋅H2O (6d) 和 (R,R)-NNN-CoCl2 (6e)，并通过 HRMS 和/或单晶 X 射线衍射对其进行了表征。络合物 6b、6e 的 ORTEP 图显示，金属中心周围的配位几何形状近似正方金字塔形。体外评估了这些化合物对 K562、293T、MCF-7、SiHa 和 SH-SY5Y 细胞系的细胞毒性。药理结果表明，大多数制备的化合物对 K562 细胞具有良好的选择性细胞毒性。其中，化合物 6a 和 6b 对所有癌细胞都具有良好的抗癌活性，对 293T 细胞的细胞毒性较小，甚至优于顺铂。

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来源期刊

Journal of Organometallic Chemistry 化学-无机化学与核化学

CiteScore

4.40

自引率

8.70%

发文量

221

审稿时长

36 days

期刊介绍： The Journal of Organometallic Chemistry targets original papers dealing with theoretical aspects, structural chemistry, synthesis, physical and chemical properties (including reaction mechanisms), and practical applications of organometallic compounds. Organometallic compounds are defined as compounds that contain metal - carbon bonds. The term metal includes all alkali and alkaline earth metals, all transition metals and the lanthanides and actinides in the Periodic Table. Metalloids including the elements in Group 13 and the heavier members of the Groups 14 - 16 are also included. The term chemistry includes syntheses, characterizations and reaction chemistry of all such compounds. Research reports based on use of organometallic complexes in bioorganometallic chemistry, medicine, material sciences, homogeneous catalysis and energy conversion are also welcome. The scope of the journal has been enlarged to encompass important research on organometallic complexes in bioorganometallic chemistry and material sciences, and of heavier main group elements in organometallic chemistry. The journal also publishes review articles, short communications and notes.