Transformation of meiotic drive into hybrid sterility in Drosophila.

IF 3.3 3区生物学 Q2 GENETICS & HEREDITY

Genetics Pub Date : 2024-10-07 DOI:10.1093/genetics/iyae133

Jackson Bladen, Hyuck-Jin Nam, Nitin Phadnis

引用次数: 0

Abstract

Hybrid male sterility is one of the fastest evolving intrinsic reproductive barriers between recently isolated populations. A leading explanation for the evolution of hybrid male sterility involves genomic conflicts with meiotic drivers in the male germline. There are, however, few examples directly linking meiotic drive to hybrid sterility. In this study, we report that the Sex-Ratio chromosome of Drosophila pseudoobscura, which causes X-chromosome drive within the USA subspecies, causes near-complete male sterility when it is moved into the genetic background of the Bogota subspecies. In addition, we show that this new form of sterility is genetically distinct from the sterility of F1 hybrid males in crosses between USA males and Bogota females. Our observations provide a tractable study system where noncryptic drive within species is transformed into strong hybrid sterility between very young subspecies.

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果蝇减数分裂驱动力转化为杂交不育。

杂交雄性不育是新近隔离的种群之间演化最快的内在生殖障碍之一。杂交雄性不育进化的一个主要解释是雄性种系中减数分裂驱动的基因组冲突。然而，将减数分裂驱动力与杂交不育直接联系起来的例子很少。在本研究中，我们报告了美国亚种中导致 X 染色体驱动的假鳞翅目果蝇性比染色体，当它被移入波哥大亚种的遗传背景中时，会导致近乎完全的雄性不育。此外，我们还发现这种新的不育形式与美国雄性和波哥大雌性杂交的 F1 杂交雄性的不育在遗传学上是不同的。我们的观察结果提供了一个可操作的研究系统，在该系统中，物种内的非隐性驱动力转变为非常年轻的亚种之间的强杂交不育性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Genetics GENETICS & HEREDITY-

CiteScore

6.90

自引率

6.10%

发文量

177

审稿时长

1.5 months

期刊介绍： GENETICS is published by the Genetics Society of America, a scholarly society that seeks to deepen our understanding of the living world by advancing our understanding of genetics. Since 1916, GENETICS has published high-quality, original research presenting novel findings bearing on genetics and genomics. The journal publishes empirical studies of organisms ranging from microbes to humans, as well as theoretical work. While it has an illustrious history, GENETICS has changed along with the communities it serves: it is not your mentor''s journal. The editors make decisions quickly – in around 30 days – without sacrificing the excellence and scholarship for which the journal has long been known. GENETICS is a peer reviewed, peer-edited journal, with an international reach and increasing visibility and impact. All editorial decisions are made through collaboration of at least two editors who are practicing scientists. GENETICS is constantly innovating: expanded types of content include Reviews, Commentary (current issues of interest to geneticists), Perspectives (historical), Primers (to introduce primary literature into the classroom), Toolbox Reviews, plus YeastBook, FlyBook, and WormBook (coming spring 2016). For particularly time-sensitive results, we publish Communications. As part of our mission to serve our communities, we''ve published thematic collections, including Genomic Selection, Multiparental Populations, Mouse Collaborative Cross, and the Genetics of Sex.