Impact of oncology pharmacy services on the management of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis.

IF 2.1 4区医学 Q3 PHARMACOLOGY & PHARMACY

American Journal of Health-System Pharmacy Pub Date : 2025-01-24 DOI:10.1093/ajhp/zxae237

Yejin Shin, Sangyoon Shin, Heejeong Ryu, Jooyi Lee, Eunkyung Euni Lee

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引用次数: 0

Abstract

Purpose: To evaluate the effect of oncology services rendered by clinical pharmacists on reducing chemotherapy-induced nausea and vomiting (CINV) and improving overall treatment experiences.

Methods: A systematic review and meta-analysis were conducted using studies retrieved from PubMed, Embase, Cochrane Central Register of Controlled Trials (CENTRAL), and Research Information Sharing Service (RISS). The incidence and severity of CINV were evaluated as primary outcomes. Secondary outcomes were patient adherence, patient satisfaction, quality of life (QoL), emergency department (ED) visits, hospitalizations, and costs.

Results: A total of 12 studies were selected for systematic review, with 8 studies eligible for meta-analysis. We found that clinical pharmacy services contributed to preventing and alleviating CINV as well as improving patient's medication adherence, treatment satisfaction, and QoL, reducing hospital visits, and achieving cost savings. In the meta-analysis, pharmacists' interventions were notably effective in reducing the incidence of nausea (odds ratio [OR], 1.917; 95% CI, 1.243-2.955; P = 0.003) and vomiting (OR, 2.491; 95% CI, 1.199-5.177; P = 0.014) during overall treatments periods relative to results in control groups. In addition, the impact of clinical pharmacy services on CINV control was greater during the delayed phase compared to the acute phase.

Conclusion: This study demonstrated the important role of clinical pharmacy services in controlling CINV and enhancing the overall treatment experience for patients with cancer. Further studies with standardized pharmacists' services and outcome measures are needed to validate our findings.

查看原文本刊更多论文

肿瘤药学服务对化疗引起的恶心和呕吐管理的影响：系统回顾与荟萃分析。

免责声明：为了加快文章的出版速度，AJHP在接受稿件后会尽快在网上发布。被录用的稿件已经过同行评审和校对，但在进行技术格式化和作者校对之前会在网上发布。目的：评估临床药剂师提供的肿瘤学服务对减少化疗引起的恶心和呕吐（CINV）以及改善整体治疗体验的影响：利用从 PubMed、Embase、Cochrane 对照试验中央注册中心 (CENTRAL) 和研究信息共享服务 (RISS) 中检索到的研究进行了系统综述和荟萃分析。CINV的发生率和严重程度为主要评估结果。次要结果包括患者依从性、患者满意度、生活质量（QoL）、急诊科就诊率、住院率和费用：共选择了 12 项研究进行系统回顾，其中 8 项研究符合荟萃分析条件。我们发现，临床药学服务有助于预防和缓解 CINV，改善患者的用药依从性、治疗满意度和 QoL，减少医院就诊次数，并节约成本。在荟萃分析中，与对照组的结果相比，药剂师的干预措施在降低整个治疗期间的恶心（几率比 [OR]，1.917；95% CI，1.243-2.955；P = 0.003）和呕吐（OR，2.491；95% CI，1.199-5.177；P = 0.014）发生率方面效果显著。此外，与急性期相比，延迟期临床药学服务对 CINV 控制的影响更大：这项研究表明，临床药学服务在控制 CINV 和改善癌症患者整体治疗体验方面发挥着重要作用。为了验证我们的研究结果，还需要进一步开展标准化药剂师服务和结果测量的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Health-System Pharmacy 医学-药学

CiteScore

2.90

自引率

18.50%

发文量

341

审稿时长

3-8 weeks

期刊介绍： The American Journal of Health-System Pharmacy (AJHP) is the official publication of the American Society of Health-System Pharmacists (ASHP). It publishes peer-reviewed scientific papers on contemporary drug therapy and pharmacy practice innovations in hospitals and health systems. With a circulation of more than 43,000, AJHP is the most widely recognized and respected clinical pharmacy journal in the world.