Enhanced Diagnostic Accuracy of Pulmonary Embolism: Integrating Low-Dose CT with V/Q SPECT.

IF 2.2 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Tomography Pub Date : 2024-08-16 DOI:10.3390/tomography10080096

Munassar Dakkam Lasloom, Mohamed Abuzaid

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引用次数: 0

Abstract

Objective: This study aimed to retrospectively assess the benefits of combining low-dose computed tomography (LDCT) with ventilation/perfusion single-photon emission computed tomography (V/Q SPECT) for the diagnosis of pulmonary embolism (PE).

Methods: A retrospective analysis was performed on 92 patients with suspected PE who underwent V/Q SPECT with ldCT (V/Q SPECT CT) between January 2020 and December 2022 at King Khalid Hospital Najran. Data were collected using the hospital's picture archiving and communication system. Scans were categorized on the basis of perfusion defects, matched or mismatched ventilation, and CT findings. The specificity of V/Q SPECT CT was compared with that of Q SPECT CT.

Results: This study included 92 patients (54 females and 38 males; median age, 53 years). The results demonstrated that V/Q SPECT CT had higher specificity (93%) than V/Q SPECT alone (88%). If CT had been used as a ventilation substitute, 21% of patients would have been reported to be positive for PE (8% false-positive), yielding a specificity of 60% for Q SPECT CT. These findings align with the existing literature, although discrepancies in specificity values were noted due to the different study designs and sample sizes.

Conclusion: This study highlights the enhanced specificity of V/Q SPECT CT compared to V/Q SPECT and Q SPECT CT alone. Including low-dose CT improves diagnostic accuracy by reducing false positives and providing detailed anatomical information. V/Q SPECT CT offers superior specificity in diagnosing PE compared with V/Q SPECT alone, supporting its use in clinical practice.

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提高肺栓塞的诊断准确性：将低剂量 CT 与 V/Q SPECT 相结合。

研究目的本研究旨在回顾性评估低剂量计算机断层扫描（LDCT）与通气/灌注单光子发射计算机断层扫描（V/Q SPECT）相结合诊断肺栓塞（PE）的益处：对2020年1月至2022年12月期间在哈立德国王医院（King Khalid Hospital Najran）接受V/Q SPECT与ldCT（V/Q SPECT CT）检查的92名疑似肺栓塞患者进行了回顾性分析。数据通过医院的图片存档和通信系统收集。根据灌注缺陷、匹配或不匹配通气以及 CT 结果对扫描结果进行分类。将 V/Q SPECT CT 的特异性与 Q SPECT CT 的特异性进行了比较：本研究共纳入 92 名患者（54 名女性，38 名男性；中位年龄 53 岁）。结果显示，V/Q SPECT CT 的特异性（93%）高于单独使用 V/Q SPECT 的特异性（88%）。如果用 CT 代替通气，21% 的患者会被报告为 PE 阳性（8% 为假阳性），Q SPECT CT 的特异性为 60%。这些发现与现有文献一致，但由于研究设计和样本量不同，特异性值也存在差异：本研究强调，与单独使用 V/Q SPECT 和 Q SPECT CT 相比，V/Q SPECT CT 的特异性更高。纳入低剂量 CT 可减少假阳性并提供详细的解剖信息，从而提高诊断准确性。与单独使用 V/Q SPECT 相比，V/Q SPECT CT 在诊断 PE 方面具有更高的特异性，支持其在临床实践中的应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tomography Medicine-Radiology, Nuclear Medicine and Imaging

CiteScore

2.70

自引率

10.50%

发文量

222

期刊介绍： TomographyTM publishes basic (technical and pre-clinical) and clinical scientific articles which involve the advancement of imaging technologies. Tomography encompasses studies that use single or multiple imaging modalities including for example CT, US, PET, SPECT, MR and hyperpolarization technologies, as well as optical modalities (i.e. bioluminescence, photoacoustic, endomicroscopy, fiber optic imaging and optical computed tomography) in basic sciences, engineering, preclinical and clinical medicine. Tomography also welcomes studies involving exploration and refinement of contrast mechanisms and image-derived metrics within and across modalities toward the development of novel imaging probes for image-based feedback and intervention. The use of imaging in biology and medicine provides unparalleled opportunities to noninvasively interrogate tissues to obtain real-time dynamic and quantitative information required for diagnosis and response to interventions and to follow evolving pathological conditions. As multi-modal studies and the complexities of imaging technologies themselves are ever increasing to provide advanced information to scientists and clinicians. Tomography provides a unique publication venue allowing investigators the opportunity to more precisely communicate integrated findings related to the diverse and heterogeneous features associated with underlying anatomical, physiological, functional, metabolic and molecular genetic activities of normal and diseased tissue. Thus Tomography publishes peer-reviewed articles which involve the broad use of imaging of any tissue and disease type including both preclinical and clinical investigations. In addition, hardware/software along with chemical and molecular probe advances are welcome as they are deemed to significantly contribute towards the long-term goal of improving the overall impact of imaging on scientific and clinical discovery.