Worse Wilms' Tumor Outcomes Associated With Chemical Complementarity for Multiple T-Cell Receptor CDR3-CMV Epitope Pairs.

IF 2.6 4区医学 Q2 GENETICS & HEREDITY

Cancer Genomics & Proteomics Pub Date : 2024-09-01 DOI:10.21873/cgp.20462

Kasey L Rigby, Michael J Diaz, Etienne C Gozlan, Dorottya B Kacsoh, Joanna J Song, Tabitha R Hudock, Andrea Chobrutskiy, Boris I Chobrutskiy, George Blanck

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引用次数: 0

Abstract

Background/aim: Wilms' tumors are pediatric renal tumors that generally have a good prognosis and outcomes. Viral illnesses have been linked to development of neoplasms and should be considered as a factor that could modulate overall survival.

Materials and methods: We considered recently developed adaptive immune receptor, genomics and bioinformatics approaches to assess the potential impact of cytomegalovirus (CMV) infections in Wilms' tumor.

Results: T-cell receptor (TCR) complementarity determining region-3 (CDR3) amino acid sequences from Wilms' tumor specimens represented by the Therapeutically Applicable Research to Generate Effective Treatments dataset were compared with known anti-CMV TCR CDR3s, indicating that cases representing the anti-CMV TCR CDR3s had worse outcomes. Then, a chemical complementarity scoring approach for the Wilms' tumor, TCR CDR3s and a series of CMV antigens further indicated that cases representing a higher chemical complementarity to the CMV antigens had worse outcomes.

Conclusion: Overall, we present a potentially novel method to assess CMV infections and identify patients who could benefit from therapies that address such infections.

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多种 T 细胞受体 CDR3-CMV 表位对的化学互补会导致 Wilms 肿瘤恶化

背景/目的：Wilms'肿瘤是小儿肾脏肿瘤，一般预后良好。病毒性疾病与肿瘤的发展有关，应将其视为影响总体生存率的因素之一：我们考虑了最近开发的适应性免疫受体、基因组学和生物信息学方法，以评估巨细胞病毒（CMV）感染对威尔姆斯肿瘤的潜在影响：将 "产生有效治疗的治疗性研究 "数据集所代表的Wilms's肿瘤标本中的T细胞受体（TCR）互补决定区-3（CDR3）氨基酸序列与已知的抗CMV TCR CDR3进行比较，结果表明，代表抗CMV TCR CDR3的病例预后较差。然后，针对 Wilms 肿瘤、TCR CDR3s 和一系列 CMV 抗原的化学互补性评分方法进一步表明，代表与 CMV 抗原化学互补性较高的病例的预后较差：总之，我们提出了一种潜在的新方法来评估CMV感染，并确定哪些患者可以从针对此类感染的疗法中获益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Genomics & Proteomics ONCOLOGY-GENETICS & HEREDITY

CiteScore

5.00

自引率

8.00%

发文量

期刊介绍： Cancer Genomics & Proteomics (CGP) is an international peer-reviewed journal designed to publish rapidly high quality articles and reviews on the application of genomic and proteomic technology to basic, experimental and clinical cancer research. In this site you may find information concerning the editorial board, editorial policy, issue contents, subscriptions, submission of manuscripts and advertising. The first issue of CGP circulated in January 2004. Cancer Genomics & Proteomics is a journal of the International Institute of Anticancer Research. From January 2013 CGP is converted to an online-only open access journal. Cancer Genomics & Proteomics supports (a) the aims and the research projects of the INTERNATIONAL INSTITUTE OF ANTICANCER RESEARCH and (b) the organization of the INTERNATIONAL CONFERENCES OF ANTICANCER RESEARCH.