Synthesis and characterization of B-type carbonated hydroxyapatite materials: Effect of carbonate content on mechanical strength and in vitro degradation

IF 2.7 4区材料科学 Q1 MATERIALS SCIENCE, CERAMICS

Boletin de la Sociedad Espanola de Ceramica y Vidrio Pub Date : 2024-07-01 DOI:10.1016/j.bsecv.2023.12.001

Hamilton Copete , Esperanza López , Carmen Baudin

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引用次数: 0

Abstract

The current approach in bone tissue engineering requires resorbable biomaterials that enhance bone formation while maintaining sufficient mechanical stability. In this work, the influence of three levels of B-type carbonate substitution in hydroxyapatite lattice on mechanical strength and degradation rate is analyzed. The inverse aqueous route has been selected as a synthesis method of four powders with carbonate substitution between 4 and 6 wt.%. X-ray fluorescence (XRF), (C-S)-Analysis, FT-Infrared, X-ray diffraction, DTA-TG and TEM were used to investigate chemical composition, type of substitution, thermal behaviour, and morphology of the powders. Disc shaped specimens were processed by uniaxial pressing and sintering in argon/CO₂ flow. Maximum temperatures of thermal treatment between 750 and 850 °C were selected to obtain similar porosity levels for the different compositions. The highest carbonate substituted material (5.3 wt.%) presented higher compressive strength and dissolution rate than the other materials showing the beneficial effect of B-type substitution in hydroxyapatite materials for bone repair.

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B 型碳化羟基磷灰石材料的合成与表征：碳酸盐含量对机械强度和体外降解的影响

目前的骨组织工程方法要求可吸收生物材料既能促进骨形成，又能保持足够的机械稳定性。本研究分析了羟基磷灰石晶格中三种程度的 B 型碳酸盐取代对机械强度和降解率的影响。四种碳酸盐取代度介于 4 至 6 wt.% 之间的粉末的合成方法均选择了反向水溶液路线。利用 X 射线荧光 (XRF)、(C-S)分析、傅立叶变换红外光谱、X 射线衍射、DTA-TG 和 TEM 来研究粉末的化学成分、替代类型、热性能和形态。圆盘状试样在氩气/二氧化碳气流中进行单轴压制和烧结处理。热处理的最高温度选择在 750 至 850 ℃ 之间，以获得不同成分的相似孔隙率水平。碳酸盐取代度最高的材料（5.3 wt.%）比其他材料具有更高的抗压强度和溶解率，这表明羟基磷灰石材料中的 B 型取代对骨修复具有有利影响。

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来源期刊

Boletin de la Sociedad Espanola de Ceramica y Vidrio 工程技术-材料科学：硅酸盐

CiteScore

5.50

自引率

2.90%

发文量

审稿时长

103 days

期刊介绍： The Journal of the Spanish Ceramic and Glass Society publishes scientific articles and communications describing original research and reviews relating to ceramic materials and glasses. The main interests are on novel generic science and technology establishing the relationships between synthesis, processing microstructure and properties of materials. Papers may deal with ceramics and glasses included in any of the conventional categories: structural, functional, traditional, composites and cultural heritage. The main objective of the Journal of the Spanish Ceramic and Glass Society is to sustain a high standard research quality by means of appropriate reviewing procedures.