The role of mitochondrial fusion and fission in immune-mediated inflammatory diseases

IF 3.7 4区医学 Q2 CELL BIOLOGY

Cellular immunology Pub Date : 2024-08-26 DOI:10.1016/j.cellimm.2024.104864

Yulai Fang , Shichen Min , Hong Shen

引用次数: 0

Abstract

Mitochondria are highly dynamic organelles that maintain their homeostasis through mitochondrial dynamics. Mitochondrial fusion and fission are two important processes of mitochondrial dynamics. There is accumulating evidence that mitochondrial fusion and fission play an important role in the development of immune-mediated inflammatory diseases. This article provides a brief review of the essential role of mitochondrial fusion and fission in immune-mediated inflammatory diseases. It will provide a novel perspective and direction for the elucidation of the pathogenesis and treatment of immune-mediated inflammatory diseases.

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线粒体融合与分裂在免疫介导的炎症性疾病中的作用

线粒体是高度动态的细胞器，通过线粒体动力学维持其平衡。线粒体融合和分裂是线粒体动力学的两个重要过程。越来越多的证据表明，线粒体融合和裂变在免疫介导的炎症性疾病的发生发展中扮演着重要角色。本文简要回顾了线粒体融合和裂变在免疫介导的炎症性疾病中的重要作用。它将为阐明免疫介导的炎症性疾病的发病机制和治疗提供一个新的视角和方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular immunology 生物-免疫学

CiteScore

8.20

自引率

2.30%

发文量

102

审稿时长

30 days

期刊介绍： Cellular Immunology publishes original investigations concerned with the immunological activities of cells in experimental or clinical situations. The scope of the journal encompasses the broad area of in vitro and in vivo studies of cellular immune responses. Purely clinical descriptive studies are not considered. Research Areas include: • Antigen receptor sites • Autoimmunity • Delayed-type hypersensitivity or cellular immunity • Immunologic deficiency states and their reconstitution • Immunologic surveillance and tumor immunity • Immunomodulation • Immunotherapy • Lymphokines and cytokines • Nonantibody immunity • Parasite immunology • Resistance to intracellular microbial and viral infection • Thymus and lymphocyte immunobiology • Transplantation immunology • Tumor immunity.