Tailored-Biomaterials Based Potential Strategies for Cardiovascular Disease.

Sukhwinder K Bhullar, Haimanti Mondal, John Thomas, Duygu Gazioglu Ruzgar, Natarajan Chandrasekaran, Amitava Mukherjee, Martin B G Jun, Stephanie M Willerth
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Abstract

Cardiovascular disease is a significant health concern worldwide, and varied effective treatment and prevention methods have been developed. Among these, tailored biomaterials-based strategies such as stents, scaffolds, patches, and drug delivery systems have emerged as a promising avenue. These devices are designed to match the mechanical and biological mechanisms of the cardiovascular system, ensuring optimal performance and compatibility. By effectively treating or preventing cardiovascular diseases, these devices have the potential to improve patient health outcomes significantly. They can restore blood flow by addressing blocked arteries and regenerate damaged cardiac tissue by delivering bioactive agents or cells directly to the affected area in a targeted, sustained, and controllable manner. Therefore, the objective of this article is to summarize the available evidence on these tailored biomaterial-based tunable cardiovascular devices. This knowledge can help to transform cardiovascular medicine for the treatment or prevention of cardiovascular disease and restore cardiac function to improve patients' quality of life.

基于定制生物材料的心血管疾病潜在治疗策略。
心血管疾病是全球关注的重大健康问题,目前已开发出多种有效的治疗和预防方法。其中,以定制生物材料为基础的策略,如支架、支架、补片和给药系统等,已成为一条前景广阔的途径。这些设备的设计与心血管系统的机械和生物机制相匹配,确保了最佳的性能和兼容性。通过有效治疗或预防心血管疾病,这些设备有望显著改善患者的健康状况。它们可以通过处理阻塞的动脉来恢复血流,并以定向、持续和可控的方式将生物活性剂或细胞直接输送到受影响的区域,从而使受损的心脏组织再生。因此,本文旨在总结这些基于生物材料的定制可调心血管装置的现有证据。这些知识有助于改变心血管医学,治疗或预防心血管疾病,恢复心脏功能,提高患者的生活质量。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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