The Current Molecular and Cellular Landscape of Chronic Obstructive Pulmonary Disease (COPD): A Review of Therapies and Efforts towards Personalized Treatment.

IF 4 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY
Luke A Farrell, Matthew B O'Rourke, Matthew P Padula, Fernando Souza-Fonseca-Guimaraes, Gaetano Caramori, Peter A B Wark, Shymali C Dharmage, Phillip M Hansbro
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引用次数: 0

Abstract

Chronic obstructive pulmonary disease (COPD) ranks as the third leading cause of global illness and mortality. It is commonly triggered by exposure to respiratory irritants like cigarette smoke or biofuel pollutants. This multifaceted condition manifests through an array of symptoms and lung irregularities, characterized by chronic inflammation and reduced lung function. Present therapies primarily rely on maintenance medications to alleviate symptoms, but fall short in impeding disease advancement. COPD's diverse nature, influenced by various phenotypes, complicates diagnosis, necessitating precise molecular characterization. Omics-driven methodologies, including biomarker identification and therapeutic target exploration, offer a promising avenue for addressing COPD's complexity. This analysis underscores the critical necessity of improving molecular profiling to deepen our comprehension of COPD and identify potential therapeutic targets. Moreover, it advocates for tailoring treatment strategies to individual phenotypes. Through comprehensive exploration-based molecular characterization and the adoption of personalized methodologies, innovative treatments may emerge that are capable of altering the trajectory of COPD, instilling optimism for efficacious disease-modifying interventions.

慢性阻塞性肺病 (COPD) 目前的分子和细胞状况:慢性阻塞性肺病(COPD)当前的分子和细胞状况:疗法回顾与个性化治疗努力。
慢性阻塞性肺病(COPD)是导致全球疾病和死亡的第三大原因。它通常由接触香烟烟雾或生物燃料污染物等呼吸道刺激物引发。这种多发性疾病表现为一系列症状和肺部异常,其特点是慢性炎症和肺功能减退。目前的疗法主要依靠维持性药物来缓解症状,但无法阻止病情发展。慢性阻塞性肺病的性质多种多样,受各种表型的影响,使得诊断更加复杂,需要精确的分子特征描述。包括生物标记物鉴定和治疗靶点探索在内的表观学驱动方法为解决慢性阻塞性肺病的复杂性提供了一条前景广阔的途径。这项分析强调了改进分子特征描述以加深我们对慢性阻塞性肺病的理解并确定潜在治疗靶点的极端必要性。此外,它还提倡根据个体表型制定治疗策略。通过基于分子特征的全面探索和采用个性化方法,可能会出现能够改变慢性阻塞性肺病发展轨迹的创新治疗方法,从而为有效的疾病改变干预措施带来希望。
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来源期刊
Proteomes
Proteomes Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
6.50
自引率
3.00%
发文量
37
审稿时长
11 weeks
期刊介绍: Proteomes (ISSN 2227-7382) is an open access, peer reviewed journal on all aspects of proteome science. Proteomes covers the multi-disciplinary topics of structural and functional biology, protein chemistry, cell biology, methodology used for protein analysis, including mass spectrometry, protein arrays, bioinformatics, HTS assays, etc. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of papers. Scope: -whole proteome analysis of any organism -disease/pharmaceutical studies -comparative proteomics -protein-ligand/protein interactions -structure/functional proteomics -gene expression -methodology -bioinformatics -applications of proteomics
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