Design and one-pot synthesis of 2H(methyl)-3-alkyl-4-oxo-3,4-dihydroquinazoline-6-sulfonamides

IF 2.218 Q2 Chemistry

Chemical Data Collections Pub Date : 2024-08-15 DOI:10.1016/j.cdc.2024.101160

引用次数: 0

Abstract

2H(Methyl)-3-alkylquinazolin-4(3H)-ones were synthesized by reactions of 2H(methyl)quinazolin-4(3H)-ones with alkyl halides. The obtained 2H(methyl)-3-alkylquinazolin-4(3H)-ones were subjected to one-pot synthesis in the presence of chlorosulfonic acid and ammonia, primary sulfonamides among bicyclic quinazolines were synthesized and were characterized by ¹H NMR, ¹³C NMR, IR and mass spectral data. The crystal structure of 2-methyl-3‑butyl‑4-oxo-3,4-dihydroquinazoline-6-sulfonamide was determined by the single-crystal X-ray diffraction method at 293 K.

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2H(甲基)-3-烷基-4-氧代-3,4-二氢喹唑啉-6-磺酰胺的设计和一步法合成

通过 2H(甲基)喹唑啉-4(3H)-酮与烷基卤化物的反应合成了 2H(甲基)-3-烷基喹唑啉-4(3H)-酮。得到的 2H(甲基)-3-烷基喹唑啉-4(3H)-酮在氯磺酸和氨存在下进行了一锅合成，合成了双环喹唑啉类中的初级磺酰胺，并通过 1H NMR、13C NMR、IR 和质谱数据对其进行了表征。在 293 K 温度下，用单晶 X 射线衍射法测定了 2-甲基-3-丁基-4-氧代-3,4-二氢喹唑啉-6-磺酰胺的晶体结构。

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来源期刊

Chemical Data Collections Chemistry-Chemistry (all)

CiteScore

6.10

自引率

0.00%

发文量

169

审稿时长

24 days

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