A novel 3D-printed brachytherapy applicator and Monte Carlo model for the treatment of conjunctival tumors

IF 1.7 4区医学 Q4 ONCOLOGY

Brachytherapy Pub Date : 2024-11-01 DOI:10.1016/j.brachy.2024.07.004

C.K. Matrosic , S. Kronenberg , H. Demirci , J.A. Hayman , H. Han , C. Lee

{"title":"A novel 3D-printed brachytherapy applicator and Monte Carlo model for the treatment of conjunctival tumors","authors":"C.K. Matrosic , S. Kronenberg , H. Demirci , J.A. Hayman , H. Han , C. Lee","doi":"10.1016/j.brachy.2024.07.004","DOIUrl":null,"url":null,"abstract":"<div><h3>PURPOSE</h3><div>To develop a custom low dose rate brachytherapy applicator for the treatment of conjunctival malignancies which leverages 3D-printing technology to provide enhanced design flexibility and availability.</div></div><div><h3>METHODS</h3><div>An elliptical shell applicator inspired by ocular surgery postoperation conformer shells was developed for the placement of the applicator around the cornea of the eye, with a central hole to provide patient comfort. The applicator featured 2 concentric circles of slots for iodine-125 seeds, providing customization of the dose distribution depending on the location of the target. The applicator was modeled using computer-aided design software. The resultant model STL file was used for 3D printing of the applicator and the development of a Monte Carlo model of the applicator and its dose distribution.</div></div><div><h3>RESULTS</h3><div>The applicator was successfully 3D printed using biocompatible resin, which could be sterilized for treatment after manual source loading. A Geant4 model of the applicator was created directly from the STL model and was applied to a phantom to estimate the dose distribution delivered by the applicator. The toroidal dose distribution allowed for treatment of the conjunctiva while reducing dose to the cornea compared to traditional eye plaque designs.</div></div><div><h3>CONCLUSIONS</h3><div>A custom 3D-printed applicator was successfully developed and modeled for the treatment of conjunctival malignancies. This novel applicator design potentially provides higher quality, more customizable dose distributions for patients and the simplicity of the design makes it accessible for any clinic with 3D-printing technology.</div></div>","PeriodicalId":55334,"journal":{"name":"Brachytherapy","volume":"23 6","pages":"Pages 712-718"},"PeriodicalIF":1.7000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brachytherapy","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1538472124001120","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

PURPOSE

To develop a custom low dose rate brachytherapy applicator for the treatment of conjunctival malignancies which leverages 3D-printing technology to provide enhanced design flexibility and availability.

METHODS

An elliptical shell applicator inspired by ocular surgery postoperation conformer shells was developed for the placement of the applicator around the cornea of the eye, with a central hole to provide patient comfort. The applicator featured 2 concentric circles of slots for iodine-125 seeds, providing customization of the dose distribution depending on the location of the target. The applicator was modeled using computer-aided design software. The resultant model STL file was used for 3D printing of the applicator and the development of a Monte Carlo model of the applicator and its dose distribution.

RESULTS

The applicator was successfully 3D printed using biocompatible resin, which could be sterilized for treatment after manual source loading. A Geant4 model of the applicator was created directly from the STL model and was applied to a phantom to estimate the dose distribution delivered by the applicator. The toroidal dose distribution allowed for treatment of the conjunctiva while reducing dose to the cornea compared to traditional eye plaque designs.

CONCLUSIONS

A custom 3D-printed applicator was successfully developed and modeled for the treatment of conjunctival malignancies. This novel applicator design potentially provides higher quality, more customizable dose distributions for patients and the simplicity of the design makes it accessible for any clinic with 3D-printing technology.

查看原文本刊更多论文

用于治疗结膜肿瘤的新型三维打印近距离放射治疗器和蒙特卡洛模型。

目的：开发一种用于治疗结膜恶性肿瘤的定制低剂量率近距离放射治疗器，利用三维打印技术提高设计的灵活性和可用性：方法：受眼科手术术后保形外壳的启发，开发了一种椭圆形外壳涂药器，用于将涂药器放置在眼球角膜周围，中央有一个孔，使患者感觉舒适。涂抹器上有两个同心圆的碘-125 粒子槽，可根据目标位置定制剂量分布。涂抹器使用计算机辅助设计软件进行建模。生成的 STL 模型文件用于涂抹器的三维打印，以及涂抹器及其剂量分布的蒙特卡罗模型的开发：结果：使用生物相容性树脂成功完成了涂抹器的三维打印。根据 STL 模型直接创建了敷贴器的 Geant4 模型，并将其应用于模型，以估算敷贴器的剂量分布。与传统的眼斑设计相比，环形剂量分布既能治疗结膜，又能减少角膜所受的剂量：结论：我们成功开发了一种定制的三维打印涂抹器，并对其进行了建模，用于治疗结膜恶性肿瘤。这种新颖的涂抹器设计有可能为患者提供更高质量、更可定制的剂量分布，而且设计简单，任何拥有三维打印技术的诊所都可以使用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Brachytherapy 医学-核医学

CiteScore

3.40

自引率

21.10%

发文量

119

审稿时长

9.1 weeks

期刊介绍： Brachytherapy is an international and multidisciplinary journal that publishes original peer-reviewed articles and selected reviews on the techniques and clinical applications of interstitial and intracavitary radiation in the management of cancers. Laboratory and experimental research relevant to clinical practice is also included. Related disciplines include medical physics, medical oncology, and radiation oncology and radiology. Brachytherapy publishes technical advances, original articles, reviews, and point/counterpoint on controversial issues. Original articles that address any aspect of brachytherapy are invited. Letters to the Editor-in-Chief are encouraged.