Does the Use of Gastric-Acid Suppressants Increase the Risk of Peritonitis in Patients Undergoing Peritoneal Dialysis? A Meta-Analysis.

IF 1.4 4区 医学 Q3 UROLOGY & NEPHROLOGY
Seminars in Dialysis Pub Date : 2024-11-01 Epub Date: 2024-08-25 DOI:10.1111/sdi.13226
Lili Yao, Linfeng Ni, Xu Wu
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Abstract

Gastric-acid suppressants (GASs) are commonly prescribed to patients undergoing peritoneal dialysis for various gastrointestinal disorders. However, long-term GAS use has been linked with the risk of enteric peritonitis in this patient population. To assess the association between the enteric peritonitis risk and GAS use in patients undergoing peritoneal dialysis for end-stage renal disease, we conducted a systematic search for relevant articles published until December 2023 in PubMed, Embase, and the Cochrane Library databases. We included 11 articles on the association between GAS use and enteric peritonitis risk in patients undergoing peritoneal dialysis. We calculated pooled odds ratios (ORs) with 95% confidence intervals (CIs) using fixed and random-effects models to obtain overall effect estimates. We also explored potential sources of heterogeneity through subgroup analyses. We qualitatively analyzed data from 11 studies (n = 1993 participants), out of which, nine studies were included in meta-analysis. The overall results revealed a significant association between the enteric peritonitis risk and the use of GASs (OR, 1.61; 95% CI, 1.26-2.05; p < 0.00001). The analysis of study design subgroups showed a significant association in retrospective cohort studies (OR, 1.70; 95% CI, 1.42-2.03; p < 0.00001) but not in case-control studies. Histamine-2 receptor antagonist (H2RA) use was significantly associated with enteric peritonitis (OR, 1.49; 95% CI, 1.05-2.11, p = 0.03), whereas proton pump inhibitor use was not (OR, 1.13; 95% CI, 0.72-1.77, p = 0.28). Our findings suggest a significant association between the development of enteric peritonitis and GAS use in patients undergoing peritoneal dialysis. However, the observed heterogeneity in study characteristics warrants caution in interpreting the results.

使用胃酸抑制剂会增加腹膜透析患者患腹膜炎的风险吗?一项 Meta 分析。
胃酸抑制剂(GAS)是腹膜透析患者治疗各种胃肠道疾病的常用处方药。然而,长期使用胃酸抑制剂与这类患者发生肠腹膜炎的风险有关。为了评估因终末期肾病而接受腹膜透析的患者中肠腹膜炎风险与 GAS 使用之间的关联,我们在 PubMed、Embase 和 Cochrane Library 数据库中对 2023 年 12 月之前发表的相关文章进行了系统性检索。我们共纳入了 11 篇关于腹膜透析患者使用 GAS 与肠道腹膜炎风险之间关系的文章。我们使用固定效应和随机效应模型计算了汇总的几率比(ORs)和 95% 的置信区间(CIs),以获得总体效应估计值。我们还通过亚组分析探讨了潜在的异质性来源。我们对 11 项研究(n = 1993 名参与者)的数据进行了定性分析,其中 9 项研究被纳入了荟萃分析。总体结果显示,肠腹膜炎风险与使用 GASs 之间存在显著关联(OR,1.61;95% CI,1.26-2.05;p
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Seminars in Dialysis
Seminars in Dialysis 医学-泌尿学与肾脏学
CiteScore
3.00
自引率
6.20%
发文量
91
审稿时长
4-8 weeks
期刊介绍: Seminars in Dialysis is a bimonthly publication focusing exclusively on cutting-edge clinical aspects of dialysis therapy. Besides publishing papers by the most respected names in the field of dialysis, the Journal has unique useful features, all designed to keep you current: -Fellows Forum -Dialysis rounds -Editorials -Opinions -Briefly noted -Summary and Comment -Guest Edited Issues -Special Articles Virtually everything you read in Seminars in Dialysis is written or solicited by the editors after choosing the most effective of nine different editorial styles and formats. They know that facts, speculations, ''how-to-do-it'' information, opinions, and news reports all play important roles in your education and the patient care you provide. Alternate issues of the journal are guest edited and focus on a single clinical topic in dialysis.
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