Alterations in plasma proteome during acute COVID-19 and recovery.

IF 6 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Medicine Pub Date : 2024-08-25 DOI:10.1186/s10020-024-00898-5

Maciej Suski, Agnieszka Olszanecka, Aneta Stachowicz, Anna Kiepura, Michał Terlecki, Józef Madej, Marek Rajzer, Rafał Olszanecki

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引用次数: 0

Abstract

Background: The severe course of COVID-19 causes cardiovascular injuries, although the mechanisms involved are still not fully recognized, linked, and understood. Their characterization is of great importance with the establishment of the conception of post-acute sequelae of COVID-19, referred to as long COVID, where blood clotting and endothelial abnormalities are believed to be the key pathomechanisms driving circulatory system impairment.

Methods: The presented study investigates temporal changes in plasma proteins in COVID-19 patients during hospitalization due to SARS-CoV-2 infection and six months after recovery by targeted SureQuant acquisition using PQ500 panel.

Results: In total, we identified 167 proteins that were differentially regulated between follow-up and hospitalization, which functionally aggregated into immune system activation, complement and coagulation cascades, interleukins signalling, platelet activation, and extracellular matrix organization. Furthermore, we found that temporal quantitative changes in acute phase proteins correlate with selected clinical characteristics of COVID-19 patients.

Conclusions: In-depth targeted proteome investigation evidenced substantial changes in plasma protein composition of patients during and recovering from COVID-19, evidencing a wide range of functional pathways induced by SARS-CoV-2 infection. In addition, we show that a subset of acute phase proteins, clotting cascade regulators and lipoproteins could have clinical value as potential predictors of long-term cardiovascular events in COVID-19 convalescents.

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急性 COVID-19 和恢复期血浆蛋白质组的变化。

背景：COVID-19 的严重病程会导致心血管损伤，但相关机制仍未得到充分认识、联系和理解。随着 COVID-19 后急性后遗症概念的确立（被称为长 COVID），血凝和内皮异常被认为是导致循环系统损伤的关键病理机制，因此对其特征进行描述具有重要意义：本研究通过使用 PQ500 面板有针对性地采集 SureQuant，调查了 COVID-19 患者在感染 SARS-CoV-2 住院期间和康复后 6 个月血浆蛋白的时间变化：结果：我们共发现167种蛋白质在随访和住院期间受到不同程度的调控，这些蛋白质在功能上可归纳为免疫系统激活、补体和凝血级联、白细胞介素信号传导、血小板激活和细胞外基质组织。此外，我们还发现急性期蛋白的时间定量变化与COVID-19患者的部分临床特征相关：结论：深入的靶向蛋白质组调查证明，COVID-19 患者在发病期间和恢复期的血浆蛋白质组成发生了重大变化，证明了 SARS-CoV-2 感染诱导的多种功能通路。此外，我们还发现一些急性期蛋白、凝血级联调节因子和脂蛋白具有临床价值，可作为 COVID-19 康复者长期心血管事件的潜在预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Medicine 医学-生化与分子生物学

CiteScore

8.60

自引率

0.00%

发文量

137

审稿时长

1 months

期刊介绍： Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.