Association Between Vitamin Intake and Colorectal Cancer: Evidence from NHANES Data.

IF 1.6 Q4 ONCOLOGY

Journal of Gastrointestinal Cancer Pub Date : 2024-12-01 Epub Date: 2024-08-26 DOI:10.1007/s12029-024-01107-6

Man Luo, Lingyi Li

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引用次数: 0

Abstract

Purpose: This study aims to investigate the associations between vitamins and colorectal cancer (CRC) based on a national sample of US adults.

Methods: A total of 6200 samples were collected from the National Health and Nutrition Examination Survey to explore the relationship between vitamins (specifically, A, C, and D) and CRC. Logistic regression models were employed to assess the associations between dietary vitamin intake and CRC.

Results: Our findings indicate a negative association between vitamin C intake and CRC. However, the associations of vitamin A and vitamin D with CRC were not statistically significant. For vitamin C, compared to the first tertile, the odds ratios (ORs) and 95% confidence intervals (CIs) were 0.91 (0.76-0.97) for the second tertile and 0.81 (0.64-0.95) for the third tertile (P < 0.01). Conversely, for vitamin A, compared to the first tertile, the odds ratios (ORs) and 95% confidence intervals (CIs) were 1.02 (0.82-1.22) for the second tertile and 1.04 (0.75-1.25) for the third tertile (P < 0.01). For vitamin D, compared to the first tertile, the odds ratios (ORs) and 95% confidence intervals (CIs) were 0.96 (0.84-1.06) for the second tertile and 1.01 (0.83-1.15) for the third tertile (P < 0.01). Additionally, the negative association between vitamin C and CRC was more pronounced among females (0.76, 0.67-0.92), individuals aged 60 and above (0.75, 0.69-0.95), and those with a BMI > 30 (0.78, 0.67-0.93).

Conclusion: Our findings suggest that higher vitamin C intake is associated with a reduced prevalence of CRC. However, further large-scale prospective cohort studies are warranted to validate our results.

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维生素摄入量与结直肠癌之间的关系：来自 NHANES 数据的证据

目的：本研究旨在通过对美国成年人进行全国性抽样调查，研究维生素与结肠直肠癌（CRC）之间的关系：方法：从美国国家健康与营养调查（National Health and Nutrition Examination Survey）中收集了 6200 个样本，以探讨维生素（特别是 A、C 和 D）与 CRC 之间的关系。我们采用逻辑回归模型来评估膳食维生素摄入量与 CRC 之间的关系：结果：我们的研究结果表明，维生素 C 摄入量与 CRC 呈负相关。然而，维生素 A 和维生素 D 与 CRC 的关系在统计学上并不显著。就维生素 C 而言，与第一分位数相比，第二分位数的几率比（ORs）和 95% 置信区间（CIs）分别为 0.91 (0.76-0.97)和 0.81 (0.64-0.95)（P 30 (0.78, 0.67-0.93)）：我们的研究结果表明，维生素 C 摄入量越高，CRC 患病率越低。结论：我们的研究结果表明，维生素 C 摄入量越高，癌症发病率越低。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Gastrointestinal Cancer ONCOLOGY-

CiteScore

3.80

自引率

0.00%

发文量

121

期刊介绍： The Journal of Gastrointestinal Cancer is a multidisciplinary medium for the publication of novel research pertaining to cancers arising from the gastrointestinal tract.The journal is dedicated to the most rapid publication possible.The journal publishes papers in all relevant fields, emphasizing those studies that are helpful in understanding and treating cancers affecting the esophagus, stomach, liver, gallbladder and biliary tree, pancreas, small bowel, large bowel, rectum, and anus. In addition, the Journal of Gastrointestinal Cancer publishes basic and translational scientific information from studies providing insight into the etiology and progression of cancers affecting these organs. New insights are provided from diverse areas of research such as studies exploring pre-neoplastic states, risk factors, epidemiology, genetics, preclinical therapeutics, surgery, radiation therapy, novel medical therapeutics, clinical trials, and outcome studies.In addition to reports of original clinical and experimental studies, the journal also publishes: case reports, state-of-the-art reviews on topics of immediate interest or importance; invited articles analyzing particular areas of pancreatic research and knowledge; perspectives in which critical evaluation and conflicting opinions about current topics may be expressed; meeting highlights that summarize important points presented at recent meetings; abstracts of symposia and conferences; book reviews; hypotheses; Letters to the Editors; and other items of special interest, including:Complex Cases in GI Oncology: This is a new initiative to provide a forum to review and discuss the history and management of complex and involved gastrointestinal oncology cases. The format will be similar to a teaching case conference where a case vignette is presented and is followed by a series of questions and discussion points. A brief reference list supporting the points made in discussion would be expected.