Temperature modulates dominance of a superinfecting Arctic virus in its unicellular algal host.

IF 10.8 1区环境科学与生态学 Q1 ECOLOGY

ISME Journal Pub Date : 2024-01-08 DOI:10.1093/ismejo/wrae161

Claudia Meyer, Victoria L N Jackson, Keith Harrison, Ioanna Fouskari, Henk Bolhuis, Yael A Artzy-Randrup, Jef Huisman, Adam Monier, Corina P D Brussaard

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引用次数: 0

Abstract

Complex virus-virus interactions can arise when multiple viruses coinfect the same host, impacting infection outcomes with broader ecological and evolutionary significance for viruses and host. Yet, our knowledge regarding virus competition is still limited, especially for single-celled eukaryotic host-virus systems. Here, we report on mutual interference of two dsDNA viruses, MpoV-45T and MpoV-46T, competing for their Arctic algal host Micromonas polaris. Both viruses affected each other's gene expression and displayed reduced genome replication during coinfection. MpoV-45T was the dominant virus, likely due to interference in the DNA replication of is competitor. Even when its coinfection was delayed, the dominant virus still prevailed while genome production of the other virus was strongly suppressed. This contrasts with typical superinfection exclusion, where the primary infection prevents secondary infection by other viruses. Higher temperature made the suppressed virus a stronger competitor, signifying that global warming is likely to alter virus-virus interactions in Arctic waters.

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温度调节北极超级感染病毒在其单细胞藻类宿主中的优势。

当多种病毒共同感染同一宿主时，会产生复杂的病毒-病毒相互作用，影响感染结果，对病毒和宿主具有更广泛的生态和进化意义。然而，我们对病毒竞争的了解仍然有限，尤其是对单细胞真核生物宿主-病毒系统而言。在这里，我们报告了两种 dsDNA 病毒 MpoV-45 T 和 MpoV-46 T 在竞争北极藻类宿主 Micromonas polaris 时的相互干扰。在共感染过程中，两种病毒都会影响对方的基因表达并减少基因组复制。MpoV-45 T 是优势病毒，这可能是由于干扰了竞争对手的 DNA 复制。即使延迟共感染，优势病毒仍占优势，而另一种病毒的基因组生产则受到强烈抑制。这与典型的超感染排斥形成鲜明对比，在超感染排斥中，主要感染会阻止其他病毒的二次感染。温度升高使被抑制的病毒成为更强的竞争者，这表明全球变暖可能会改变北极水域病毒与病毒之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ISME Journal 环境科学-生态学

CiteScore

22.10

自引率

2.70%

发文量

171

审稿时长

2.6 months

期刊介绍： The ISME Journal covers the diverse and integrated areas of microbial ecology. We encourage contributions that represent major advances for the study of microbial ecosystems, communities, and interactions of microorganisms in the environment. Articles in The ISME Journal describe pioneering discoveries of wide appeal that enhance our understanding of functional and mechanistic relationships among microorganisms, their communities, and their habitats.