Spatial diversity of in vivo tissue immunity.

IF 4.8 4区 医学 Q2 IMMUNOLOGY
Yu Miyamoto, Masaru Ishii
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引用次数: 0

Abstract

The immune system exhibits spatial diversity in in vivo tissues. Immune cells are strategically distributed within tissues to maintain the organ integrity. Advanced technologies such as intravital imaging and spatial transcriptomics have revealed the spatial heterogeneity of immune cell distribution and function within organs such as the liver, kidney, intestine, and lung. In addition, these technologies visualize nutrient and oxygen environments across tissues. Recent spatial analyses have suggested that a functional immune niche is determined by interactions between immune and non-immune cells in an appropriate nutrient and oxygen environment. Understanding the spatial communication between immune cells, environment, and surrounding non-immune cells is crucial for developing strategies to control immune responses and effectively manage inflammatory diseases.

体内组织免疫的空间多样性。
免疫系统在体内组织中表现出空间多样性。免疫细胞在组织内呈策略性分布,以保持器官的完整性。显微成像和空间转录组学等先进技术揭示了免疫细胞在肝、肾、肠和肺等器官内分布和功能的空间异质性。此外,这些技术还能将各组织的营养和氧气环境可视化。最近的空间分析表明,功能性免疫龛是由免疫细胞和非免疫细胞在适当的营养和氧气环境中的相互作用决定的。了解免疫细胞、环境和周围非免疫细胞之间的空间沟通对于制定控制免疫反应和有效控制炎症性疾病的策略至关重要。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International immunology
International immunology 医学-免疫学
CiteScore
9.30
自引率
2.30%
发文量
51
审稿时长
6-12 weeks
期刊介绍: International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
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