Regulated insulin secretion from human and mouse islets exclusively composed of β-cells

IF 18.9 1区医学 Q1 ENDOCRINOLOGY & METABOLISM

Nature metabolism Pub Date : 2024-08-21 DOI:10.1038/s42255-024-01117-5

引用次数: 0

Abstract

Pancreatic β-cells do not appear to require interactions with neighbouring non-β-cells (α-cells, δ-cells and γ-cells) to regulate insulin secretion. These results are clinically relevant and support the development of treatments for diabetes that involve the generation of β-like cells alone, whether from pluripotent cells or by in situ conversion of non-β-cells.

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调节完全由β细胞组成的人类和小鼠胰岛的胰岛素分泌。

胰腺β细胞似乎不需要与邻近的非β细胞（α细胞、δ细胞和γ细胞）相互作用来调节胰岛素分泌。这些结果具有临床意义，并支持开发单独生成β样细胞的糖尿病治疗方法，无论是从多能细胞还是通过非β细胞的原位转化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

27.50

自引率

2.40%

发文量

170

期刊介绍： Nature Metabolism is a peer-reviewed scientific journal that covers a broad range of topics in metabolism research. It aims to advance the understanding of metabolic and homeostatic processes at a cellular and physiological level. The journal publishes research from various fields, including fundamental cell biology, basic biomedical and translational research, and integrative physiology. It focuses on how cellular metabolism affects cellular function, the physiology and homeostasis of organs and tissues, and the regulation of organismal energy homeostasis. It also investigates the molecular pathophysiology of metabolic diseases such as diabetes and obesity, as well as their treatment. Nature Metabolism follows the standards of other Nature-branded journals, with a dedicated team of professional editors, rigorous peer-review process, high standards of copy-editing and production, swift publication, and editorial independence. The journal has a high impact factor, has a certain influence in the international area, and is deeply concerned and cited by the majority of scholars.