Oncogenic roles of long non-coding RNAs in essential glioblastoma signaling pathways.

IF 1.8 4区 医学 Q3 GENETICS & HEREDITY
Mina Lashkarboloki, Amin Jahanbakhshi, Seyed Javad Mowla, Hassan Bjeije, Bahram M Soltani
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引用次数: 0

Abstract

Glioblastoma multiforme (GBM) is an aggressive and diffuse type of glioma with the lowest survival rate in patients. The recent failure of multiple treatments suggests that targeting several targets at once may be a different strategy to overcome GBM carcinogenesis. Normal function of oncogenes and tumor suppressor genes need for the preservation of regular cellular processes, so any defects in these genes' activity, operate the corresponding signaling pathways, which initiate carcinogenic processes. Long non-coding RNAs (lncRNAs) that can be found in the cytoplasm or nucleus of the cells, control the transcription and translation of genes. LncRNAs perform a variety of functions, including epigenetic alteration, protein modification and stability, transcriptional regulation, and competition for miRNA that regulate mRNA translation through sponging miRNAs. Identification of various oncogenic lncRNAs and their multiple roles in brain cancers making them potential candidates for use as glioma diagnostic, prognostic, and therapeutic targets in the future. This study highlighted multiple oncogenic lncRNAs and classified them into different signaling pathways based on the regulated target genes in glioblastoma.

长非编码 RNA 在胶质母细胞瘤重要信号通路中的致癌作用。
多形性胶质母细胞瘤(GBM)是一种侵袭性弥漫型胶质瘤,患者存活率最低。最近多种治疗方法的失败表明,同时针对多个靶点可能是克服多形性胶质母细胞瘤癌变的不同策略。致癌基因和抑癌基因的正常功能需要维持正常的细胞过程,因此这些基因活性的任何缺陷都会使相应的信号通路起作用,从而启动致癌过程。长非编码 RNA(lncRNA)存在于细胞的细胞质或细胞核中,控制着基因的转录和翻译。LncRNA 具有多种功能,包括表观遗传学改变、蛋白质修饰和稳定性、转录调控,以及通过海绵状 miRNA 与调控 mRNA 翻译的 miRNA 竞争。各种致癌lncRNA的鉴定及其在脑癌中的多重作用使它们成为未来胶质瘤诊断、预后和治疗靶点的潜在候选者。这项研究强调了多种致癌 lncRNA,并根据胶质母细胞瘤中受调控的靶基因将它们归类为不同的信号通路。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Journal of neurogenetics
Journal of neurogenetics 医学-神经科学
CiteScore
4.40
自引率
0.00%
发文量
13
审稿时长
>12 weeks
期刊介绍: The Journal is appropriate for papers on behavioral, biochemical, or cellular aspects of neural function, plasticity, aging or disease. In addition to analyses in the traditional genetic-model organisms, C. elegans, Drosophila, mouse and the zebrafish, the Journal encourages submission of neurogenetic investigations performed in organisms not easily amenable to experimental genetics. Such investigations might, for instance, describe behavioral differences deriving from genetic variation within a species, or report human disease studies that provide exceptional insights into biological mechanisms
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