Bacterial Persister Cells and Development of Antibiotic Resistance in Chronic Infections: An Update.

IF 2.7 4区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
British Journal of Biomedical Science Pub Date : 2024-08-07 eCollection Date: 2024-01-01 DOI:10.3389/bjbs.2024.12958
Anil Philip Kunnath, Mohamed Suodha Suoodh, Dinesh Kumar Chellappan, Jestin Chellian, Kishneth Palaniveloo
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引用次数: 0

Abstract

The global issue of antimicrobial resistance poses significant challenges to public health. The World Health Organization (WHO) has highlighted it as a major global health threat, causing an estimated 700,000 deaths worldwide. Understanding the multifaceted nature of antibiotic resistance is crucial for developing effective strategies. Several physiological and biochemical mechanisms are involved in the development of antibiotic resistance. Bacterial cells may escape the bactericidal actions of the drugs by entering a physiologically dormant state known as bacterial persistence. Recent findings in this field suggest that bacterial persistence can be one of the main sources of chronic infections. The antibiotic tolerance developed by the persister cells could tolerate high levels of antibiotics and may give rise to persister offspring. These persister offspring could be attributed to antibiotic resistance mechanisms, especially in chronic infections. This review attempts to shed light on persister-induced antibiotic resistance and the current therapeutic strategies.

细菌持久细胞与慢性感染中抗生素耐药性的发展:最新进展。
抗菌药耐药性这一全球性问题给公共卫生带来了重大挑战。世界卫生组织(WHO)强调,抗生素耐药性是一个重大的全球健康威胁,估计会导致全球 70 万人死亡。了解抗生素耐药性的多面性对于制定有效的战略至关重要。抗生素耐药性的产生涉及多种生理和生化机制。细菌细胞可能会进入一种生理休眠状态,即细菌持续存在状态,从而逃避药物的杀菌作用。该领域的最新研究结果表明,细菌持久存在可能是慢性感染的主要来源之一。持久细胞产生的抗生素耐受性可以耐受高浓度的抗生素,并可能产生持久细胞后代。这些宿主后代可能是抗生素耐药性机制的产物,尤其是在慢性感染中。本综述试图阐明持久性细胞诱导的抗生素耐药性和当前的治疗策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
British Journal of Biomedical Science
British Journal of Biomedical Science 医学-医学实验技术
CiteScore
4.40
自引率
15.80%
发文量
29
审稿时长
>12 weeks
期刊介绍: The British Journal of Biomedical Science is committed to publishing high quality original research that represents a clear advance in the practice of biomedical science, and reviews that summarise recent advances in the field of biomedical science. The overall aim of the Journal is to provide a platform for the dissemination of new and innovative information on the diagnosis and management of disease that is valuable to the practicing laboratory scientist.
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