Use of frozen native feces for fecal microbiota transplantation in recurrent Clostridioides difficile infection: a simple way to improve the efficiency of donor feces preparation.
Rachel Sintes, Paul McLellan, Gabriele Navelli, Cécilia Landman, Sandrine Delage, Sandrine Truong, Nicolas Benech, Nathalie Kapel, Alicia Moreino Sabater, Aurélie Schnuriger, Catherine Eckert, Alexandre Bleibtreu, Anne-Christine Joly, Harry Sokol
{"title":"Use of frozen native feces for fecal microbiota transplantation in recurrent <i>Clostridioides difficile</i> infection: a simple way to improve the efficiency of donor feces preparation.","authors":"Rachel Sintes, Paul McLellan, Gabriele Navelli, Cécilia Landman, Sandrine Delage, Sandrine Truong, Nicolas Benech, Nathalie Kapel, Alicia Moreino Sabater, Aurélie Schnuriger, Catherine Eckert, Alexandre Bleibtreu, Anne-Christine Joly, Harry Sokol","doi":"10.1128/aac.00734-24","DOIUrl":null,"url":null,"abstract":"<p><p>Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent <i>Clostridioides difficile</i> infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (<i>P</i> = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.</p>","PeriodicalId":8152,"journal":{"name":"Antimicrobial Agents and Chemotherapy","volume":null,"pages":null},"PeriodicalIF":4.1000,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Antimicrobial Agents and Chemotherapy","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1128/aac.00734-24","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"MICROBIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Preparing fecal microbiota transplants immediately after donation is resource-intensive, and a proportion are destroyed following abnormal screening results. We retrospectively compared two processes, frozen fecal preparation (FFP) and fresh native frozen preparation (FNFP), for clinical efficacy in the treatment of recurrent Clostridioides difficile infection (rCDI). FFP and FNFP were similarly effective with clinical success rates of 76.7% and 86.7% (P = 0.32), respectively. FNFP is an efficient procedure that saves resources while maintaining clinical efficacy in rCDI.
期刊介绍:
Antimicrobial Agents and Chemotherapy (AAC) features interdisciplinary studies that build our understanding of the underlying mechanisms and therapeutic applications of antimicrobial and antiparasitic agents and chemotherapy.